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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   EPAC2 Antibody   

EPAC2 Antibody

  • WB - EPAC2 Antibody ASC11419
    Western blot analysis of EPAC2 in rat liver tissue lysate with EPAC2 antibody at 1 µg/mL in (A) the absence and (B) the presence of blocking peptide.
  • IHC - EPAC2 Antibody ASC11419
    Immunohistochemistry of EPAC3 in mouse liver tissue with EPAC3 antibody at 2.5 µg/mL.
  • IF - EPAC2 Antibody ASC11419
    Immunofluorescence of EPAC2 in mouse liver tissue with EPAC2 antibody at 20 µg/mL.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q8WZA2
Other Accession NP_008954, 155030204
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW 115522 Da
Application Notes EPAC2 antibody can be used for detection of EPAC1 by Western blot at 1 µg/mL. Antibody can also be used for immunohistochemistry starting at 2.5 µg/mL. For immunofluorescence start at 20 µg/mL.
Additional Information
Gene ID 11069
Target/Specificity RAPGEF4; At least two isoforms of EPAC2 are known to exist; this antibody will detect only the larger isoform. EPAC2 antibody is predicted to not cross-react with EPAC2
Reconstitution & Storage EPAC2 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
PrecautionsEPAC2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms CGEF2, EPAC2
Function Guanine nucleotide exchange factor (GEF) for RAP1A, RAP1B and RAP2A small GTPases that is activated by binding cAMP. Seems not to activate RAB3A. Involved in cAMP-dependent, PKA- independent exocytosis through interaction with RIMS2 (By similarity).
Cellular Location Cytoplasm. Membrane; Peripheral membrane protein
Tissue Location Predominantly expressed in brain and adrenal gland. Isoform 2 is expressed in liver. Isoform 1 is expressed in liver at very low levels
Research Areas
Citations (0)

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EPAC2 Antibody: EPAC2, also known as Rap guanine nuclear exchange factor 4 and cAMPGEF-II, is belongs to a family of cyclic adenosine monophosphate (cAMP) binding proteins with guanine nucleotide exchange factor. Like the related protein EPAC1, EPAC2 signaling plays a role in numerous cellular processes such as integrin-mediated cell adhesion, muscle contraction, learning and memory, cell proliferation, and inflammation. Recent evidence suggests that EPAC2 induces synapse remodeling and depression, with mutations in its gene being found in patients with autism.


Ueno H, Shibasaki T, Iwanaga T, et al. Characterization of the gene EPAC2: structure, chromosomal localization, tissue expression, and identification of the liver-specific isoform. Genomics 2001; 78:91-8
Grandoch M, Roscioni SS, and Schmidt M. The role of Epac proteins, novel cAMP mediators, in the regulation of immune, lung and neuronal function. Brit. J. Pharm. 2010; 159:265-84
Holz GG, Kang G, Harbeck M, et al. Cell physiology of cAMP sensor Epac. J. Physiol. 2006; 577:5-15

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$ 310.00
Cat# ASC11419
(40 western blots)
Availability: 5-7days
Bulk Size
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