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SPINK2 Antibody

  • WB - SPINK2 Antibody ASC11432
    Western blot analysis of SPINK2 in mouse heart tissue lysate with SPINK2 antibody at 1 µg/mL in (A) the absence and (B) the presence of blocking peptide.
  • IHC - SPINK2 Antibody ASC11432
    Immunohistochemistry of SPINK2 in mouse testis tissue with SPINK2 antibody at 2.5 µg/mL.
  • IF - SPINK2 Antibody ASC11432
    Immunofluorescence of SPINK2 in mouse testis tissue with SPINK2 antibody at 20 µg/mL.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P20155
Other Accession NP_065804, 10863911
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW 9291 Da
Application Notes SPINK2 antibody can be used for detection of SPINK2 by Western blot at 1 µg/mL. Antibody can also be used for immunohistochemistry starting at 2.5 µg/mL. For immunofluorescence start at 20 µg/mL.
Additional Information
Gene ID 6691
Target/Specificity SPINK2; SPINK2 antibody is predicted to not cross-react with other SPINK family members.
Reconstitution & Storage SPINK2 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
PrecautionsSPINK2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Function Strong inhibitor of acrosin in male and/or female genital tract. Also inhibits trypsin.
Cellular Location Secreted.
Tissue Location Expressed in epididymis (at protein level).
Research Areas
Citations (0)

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SPINK2 Antibody: Human serine proteinase inhibitor Kazal-type 2 (SPINK2) is required for maintaining normal spermatogenesis and potentially regulates serine protease-mediated apoptosis in male germ cells. It contains a typical kazal domain composed by six cysteine residues forming three disulfide bridges. SPINK2 functions as a trypsin/acrosin inhibitor and is synthesized mainly in the testis and seminal vesicle where its activity is engaged in fertility. SPINK2 plays a role in the pathogenesis of hereditary and chronic pancreatitis.


Lee B, Park I, Jin S, et al. Impaired spermatogenesis and fertility in mice carrying a mutation in the Spink2 gene expressed predominantly in testes. J. Biol. Chem. 2011; 286:29108-17
Chen T, Lee TR, Liang WG, et al. Identification of trypsin-inhibitory site and structure determination of human SPINK2 serine proteinase inhibitor. Proteins 2009; 77:209-19.
Liddle RA. Pathophysiology of SPINK mutations in pancreatic development and disease. Endocrinol. Metab. Clin. North Am. 2006; 35:345-56.

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$ 310.00
Cat# ASC11432
(40 western blots)
Availability: 5-7days
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