|Application ||WB, IHC-P, IF, E|
|Other Accession||NP_612636, 154426278|
|Calculated MW||50429 Da|
|Application Notes||MLIP antibody can be used for detection of MLIP by Western blot at 1 µg/mL. Antibody can also be used for immunohistochemistry starting at 5 µg/mL. For immunofluorescence start at 20 µg/mL.|
|Target/Specificity||MLIP; At least three isoforms of MLIP are known to exist.|
|Reconstitution & Storage||MLIP antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.|
|Precautions||MLIP Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Cellular Location||Nucleus. Nucleus envelope. Nucleus, PML body|
|Tissue Location||Primarily expressed in heart and skeletal muscle. Also detected in liver.|
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Provided below are standard protocols that you may find useful for product applications.
MLIP Antibody: The muscle-enriched A-type lamin-interacting protein (MLIP) is ubiquitously expressed, although most predominantly in heart, skeletal and smooth muscle, and interacts directly and co-localizes with lamin A and C in the nuclear envelope. MLIP also co-localizes with promyelocytic leukemia (PML) bodies within the nucleus. Decreasing lamin A/C expression with siRNA results in the upregulation and mislocalization of MLIP, suggesting that MLIP localization to the nuclear envelope is dependent on the lamin proteins. It has been suggested that MLIP may function as a tethering protein linking LMNA to factors within the nuclear envelope of within PML bodies
Ahmady E, Deeke SA, Rabaa S, et al. Identification of a novel muscle A-type lamin-interacting protein (MLIP). J. Biol. Chem. 2011; 286:19702-13.
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