|Application ||WB, IF, E|
|Other Accession||NP_775756, 153945734|
|Reactivity||Human, Mouse, Rat|
|Calculated MW||115005 Da|
|Application Notes||TSHZ2 antibody can be used for detection of TSHZ2 by Western blot at 1 µg/mL. Antibody can also be used for immunofluorescence starting at 20 µg/mL. For immunofluorescence start at 5 µg/mL.|
|Reconstitution & Storage||TSHZ2 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.|
|Precautions||TSHZ2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||C20orf17, TSH2, ZNF218|
|Function||Probable transcriptional regulator involved in developmental processes. May act as a transcriptional repressor (Potential).|
|Tissue Location||Expressed in brain; strongly reduced in post- mortem elderly subjects with Alzheimer disease|
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Provided below are standard protocols that you may find useful for product applications.
TSHZ2 Antibody: The Teashirt zinc finger homeobox (TSHZ) family comprise a family of evolutionarily conserved transcription factors that, in Drosophila, are active in specific body parts for patterning, but whose function in vertebrates is less clear. In mice, the known three TSHZ proteins are expressed in distinct patterns in the developing and adult brain, suggesting that they play a role in the establishment of regional identity and specification of cell types within the brain. Recent experiments have shown that the expression of TSHZ2 is frequently downregulated in most breast and prostate cancers and its promoter was unmethylated in virtually all cases, suggesting this family of proteins may also be involved in carcinogenesis.
Caubit X, Core N, Boned A, et al. Vertebrate orthologues of the Drosophila region-specific patterning gene teashirt. Mech. Dev. 2000; 91:445-8.
Santos JS, Fonseca NA, Vieira CP, et al. Phylogeny of the Teashirt-related zinc finger (tshz) gene family and analysis of the developmental expression of tshz2 and tshz3 in the zebrafish. Dev. Dyn. 2010; 239:1010-8.
Caubit X, Tiveron MC, Cremer H, et al. Expression patterns of the three Teashirt-related genes define specific boundaries in the developing and postnatal mouse forebrain. J. Comp. Neurol. 2005; 486:76-88.
Yamamoto M, Cid E, Bru S, et al. Rare and frequent promoter methylation, respectively, of TSHZ2 and 3 genes that are both downregulated in expression in breast and prostate cancers. PLoS ONE 2011; 6:e17149.
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