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RNASET2 Antibody

  • WB - RNASET2 Antibody ASC11454
    Western blot analysis of RNASET2 in SW480 cell lysate with RNASET2 antibody at 1 µg/mL in (A) the absence and (B) the presence of blocking peptide.
  • ICC - RNASET2 Antibody ASC11454
    Immunocytochemistry of RNASET2 in SW480 cells with RNASET2 antibody at 2.5 µg/ml.
  • IF - RNASET2 Antibody ASC11454
    Immunofluorescence of RNASET2 in SW480 cells with RNASET2 antibody at 5 µg/ml.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession O00584
Other Accession NP_003721, 5231228
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW 29481 Da
Application Notes RNASET2 antibody can be used for detection of FOXRED2 by Western blot at 1 µg/mL.
Additional Information
Gene ID 8635
Target/Specificity RNASET2;
Reconstitution & Storage RNASET2 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
PrecautionsRNASET2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms RNASE6PL
Function Has ribonuclease activity, with higher activity at acidic pH. Probably is involved in lysosomal degradation of ribosomal RNA (By similarity). Probably plays a role in cellular RNA catabolism.
Cellular Location Secreted. Lysosome lumen. Endoplasmic reticulum lumen. Note=Subcellular fractionation of transfected ovarian cancer cells reveals full-length RNASET2 in the endoplasmic reticulum fraction and the 2 smaller RNASET2 proteolytic products in the lysosome fraction
Tissue Location Ubiquitous. Higher expression levels observed in the temporal lobe and fetal brain
Research Areas
Citations (0)

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RNASET2 Antibody: RNASET2 is a novel member of the Rh/T2/S-glycoprotein class of extracellular ribonucleases. It is a single copy gene that maps to 6q27, a region associated with human malignancies and chromosomal rearrangement, and has been suggested to function as a tumor suppressor protein. Its expression is suppressed in Human T-cell Leukemia Virus type 1 (HTLV-1) infected cells following the binding of the HTLV-1 Tax protein to the RNASET2 promoter. As Adult T-cell leukemia (ATL) is one of the primary diseases caused by HTLV-1 infection, a reduction in the level of RNASET2 by Tax may play a role in ATL development.


Acquati F, Morelli C, Cinquetti R, et al. Cloning and characterization of a senescence inducing and class II tumor suppressor gene in ovarian carcinoma at chromosome region 6q27. Oncogene 2001; 20:980-8.
Campomenosi P, Salis S, Lingqvist C, et al. Characterization of RNASET2, the first human member of the Rh/T2/S family of glycoproteins. Arch. Biochm. Biophys. 2006; 449:17-26
Polakowski N, Han H, and Lemasson I. Direct inhibition of RNase T2 expression by the HLTV-1 viral protein Tax. Viruses 2011; 3:1485-500.

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$ 330.00
Cat# ASC11454
Availability: 5-7days
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