|Application ||WB, IF, ICC, E|
|Other Accession||NP_003721, 5231228|
|Reactivity||Human, Mouse, Rat|
|Calculated MW||29481 Da|
|Application Notes||RNASET2 antibody can be used for detection of FOXRED2 by Western blot at 1 µg/mL.|
|Reconstitution & Storage||RNASET2 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.|
|Precautions||RNASET2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Has ribonuclease activity, with higher activity at acidic pH. Probably is involved in lysosomal degradation of ribosomal RNA (By similarity). Probably plays a role in cellular RNA catabolism.|
|Cellular Location||Secreted. Lysosome lumen. Endoplasmic reticulum lumen. Note=Subcellular fractionation of transfected ovarian cancer cells reveals full-length RNASET2 in the endoplasmic reticulum fraction and the 2 smaller RNASET2 proteolytic products in the lysosome fraction|
|Tissue Location||Ubiquitous. Higher expression levels observed in the temporal lobe and fetal brain|
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Provided below are standard protocols that you may find useful for product applications.
RNASET2 Antibody: RNASET2 is a novel member of the Rh/T2/S-glycoprotein class of extracellular ribonucleases. It is a single copy gene that maps to 6q27, a region associated with human malignancies and chromosomal rearrangement, and has been suggested to function as a tumor suppressor protein. Its expression is suppressed in Human T-cell Leukemia Virus type 1 (HTLV-1) infected cells following the binding of the HTLV-1 Tax protein to the RNASET2 promoter. As Adult T-cell leukemia (ATL) is one of the primary diseases caused by HTLV-1 infection, a reduction in the level of RNASET2 by Tax may play a role in ATL development.
Acquati F, Morelli C, Cinquetti R, et al. Cloning and characterization of a senescence inducing and class II tumor suppressor gene in ovarian carcinoma at chromosome region 6q27. Oncogene 2001; 20:980-8.
Campomenosi P, Salis S, Lingqvist C, et al. Characterization of RNASET2, the first human member of the Rh/T2/S family of glycoproteins. Arch. Biochm. Biophys. 2006; 449:17-26
Polakowski N, Han H, and Lemasson I. Direct inhibition of RNase T2 expression by the HLTV-1 viral protein Tax. Viruses 2011; 3:1485-500.
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