|Application ||WB, IF, ICC, E|
|Other Accession||NP_037445, 9558721|
|Reactivity||Human, Mouse, Rat|
|Calculated MW||13575 Da|
|Application Notes||YPEL1 antibody can be used for detection of YPEL1 by Western blot at 1 µg/mL. Antibody can also be used for immunocytochemistry starting at 2.5 µg/mL. For immunofluorescence start at 2.5 µg/mL.|
|Reconstitution & Storage||YPEL1 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.|
|Precautions||YPEL1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May play a role in epithelioid conversion of fibroblasts.|
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Provided below are standard protocols that you may find useful for product applications.
YPEL1 Antibody: YPEL1 (yippee-like 1) is thought to play a role in the epitheloid conversion of fibroblasts and the regulation of the cellular morphology. It is a 119 amino acid protein that localizes to the nucleus and belongs to a family of yippee-like proteins that include YPEL2 - 5, all of which localize to the centrosome and nucleus and are widely expressed in both adult and fetal tissue. The family of human YPEL proteins share a high degree of sequence homology with their rodent homologs, suggesting a conserved function between species. YPEL1 might be an important factor during the development and malignant transformation of tissues.
Farlie P, Reid C, Wilcox S, et al. YPEL1: a novel nuclear protein that induces an epithelial-like morphology in fibroblasts. Genes Cells 2001; 6:619-29.
Hosono K, Sasaki T, Minoshima S, et al. Identification and characterization of a novel gene family YPEL in a wide spectrum of eukaryotic species. Gene 2004; 340: 31-43
Abiatari I, Kiladze M, Kerkadze V, et al. Expression of YPEL1 in pancreatic cancer cell lines and tissues. Georgian Med. News 2009; (175):60-2.
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