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YPEL3 Antibody

  • WB - YPEL3 Antibody ASC11458
    Western blot analysis of YPEL3 in A-20 cell lysate with YPEL3 antibody at 1 µg/mL in (A) the absence and (B) the presence of blocking peptide
  • ICC - YPEL3 Antibody ASC11458
    Immunocytochemistry of YPEL3 in A20 cells with YPEL3 antibody at 2.5 µg/mL.
  • IF - YPEL3 Antibody ASC11458
    Immunofluorescence of YPEL3 in A20 cells with YPEL3 antibody at 5 µg/mL.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P61236
Other Accession NP_113665, 117956405
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW 13608 Da
Application Notes YPEL3 antibody can be used for detection of YPEL3 by Western blot at 1 µg/mL. Antibody can also be used for immunocytochemistry starting at 2.5 µg/mL. For immunofluorescence start at 2.5 µg/mL.
Additional Information
Gene ID 83719
Target/Specificity YPEL3;
Reconstitution & Storage YPEL3 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
PrecautionsYPEL3 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name YPEL3
Function Involved in proliferation and apoptosis in myeloid precursor cells.
Cellular Location Nucleus, nucleolus
Tissue Location Widely expressed.
Citations (0)

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YPEL3 Antibody: YPEL3 (yippee-like 3) belongs to a family of five yippee-like proteins, all of which localize to the centrosome or mitotic spindle and are widely expressed in both adult and fetal tissue. This localization plus the fact that the family of human YPEL proteins share a high degree of sequence homology across species suggests that these proteins may have a conserved function involved in cell division. YPEL3 is a p53-regulated gene whose expression is induced by DNA damage and in turn induces cellular senescence. It appears to function as a tumor suppressor as it is downregulated in colon and breast tumors.


Hosono K, Sasaki T, Minoshima S, et al. Identification and characterization of a novel gene family YPEL in a wide spectrum of eukaryotic species. Gene 2004; 340: 31-43.
Kelley K, Miller KR, Todd A, et al. YPEL3, a p53-regulated gene that induces cellular senescence. Cancer Res. 2010; 70:3566-75.
Tuttle R, Simon R, Hitch DC, et al. Senescence-associated gene YPEL3 is downregulated in human tumors. Ann. Surg. Oncol. 2011; 18:1791-6.
Tuttle R, Miller KR, Maiorano JN, et al. Novel senescence associated gene, YPEL3, is repressed by estrogen in ER+ mammary tumor cells and required for tamoxifen-induced cellular senescence. Int. J. Cancer 2011; epub.

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$ 310.00
Cat# ASC11458
(40 western blots)
Availability: 5-7days
Bulk Size
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