|Application ||WB, IF, ICC, E|
|Other Accession||NP_659445, 219539|
|Calculated MW||14301 Da|
|Application Notes||YPEL4 antibody can be used for detection of YPEL4 by Western blot at 1 μg/mL.|
|Target/Specificity||YPEL4 antibody was raised against a 12 amino acid synthetic peptide near the amino terminus of human YPEL4.|
The immunogen is located within the first 50 amino acids of YPEL4.
|Reconstitution & Storage||YPEL4 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.|
|Precautions||YPEL4 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Cellular Location||Nucleus, nucleolus|
|Tissue Location||Widely expressed. Detected adult brain, lung, colon, small intestine and ovary, and in fetal brain, lung, liver and spleen.|
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Provided below are standard protocols that you may find useful for product applications.
YPEL4 Antibody: YPEL4 (yippee-like 4) belongs to a family of five yippee-like proteins, all of which localize to the centrosome or mitotic spindle and are widely expressed in both adult and fetal tissue. This localization plus the fact that the family of human YPEL proteins share a high degree of sequence homology across species suggests that these proteins may have a conserved function involved in cell division. YPEL4 is ubiquitously expressed in adult tissues and has been shown to associate with the major vault protein (MVP). It has been suggested that MVP can inhibit YPEL4's ability to activate Elk-1 in the MAPK signaling pathway.
Hosono K, Sasaki T, Minoshima S, et al. Identification and characterization of a novel gene family YPEL in a wide spectrum of eukaryotic species. Gene 2004; 340: 31-43
Liang P, Wan Y, Yan Y, et al. MVP interacts with YPEL4 and inhibits YPEL4-mediated activities of the ERK signal pathway. Biochem. Cell. Biol. 2010; 88:445-50.
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