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>   home   >   Products   >   Primary Antibodies   >   Neuroscience   >   TMEM106B Antibody   

TMEM106B Antibody

  • WB - TMEM106B Antibody ASC11462
    Western blot analysis of TMEM106B in human brain tissue lysate with TMEM106B antibody at 1 µg/mL in (A) the absence and (B) the presence of blocking peptide.
  • IHC - TMEM106B Antibody ASC11462
    Immunohistochemistry of TMEM106B in human liver tissue with TMEM106B antibody at 2.5 µg/mL.
  • IF - TMEM106B Antibody ASC11462
    Immunofluorescence of TMEM106B in human liver tissue with TMEM106A antibody at 20 µg/mL.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9NUM4
Other Accession NP_060844, 40254893
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW Predicted: 30 kDa

Observed: 33 kDa
Application Notes TMEM106B antibody can be used for detection of TMEM106B by Western blot at 1 µg/mL. Antibody can also be used for immunohistochemistry starting at 2.5 µg/mL. For immunofluorescence start at 2.5 µg/mL.
Additional Information
Gene ID 54664
Target/Specificity TMEM106B; This TMEM106B antibody is predicted to have no cross-reactivity to TMEM106A.
Reconstitution & Storage TMEM106B antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
PrecautionsTMEM106B Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TMEM106B
Function Involved in dendrite morphogenesis and maintenance by regulating lysosomal trafficking via its interaction with MAP6. May act by inhibiting retrograde transport of lysosomes along dendrites. Required for dendrite branching.
Cellular Location Late endosome membrane; Single-pass type II membrane protein. Lysosome membrane; Single-pass type II membrane protein
Tissue Location Expressed in frontal cortex.
Research Areas
Citations (0)

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TMEM106B Antibody: Transmembrane protein 106B (TMEM106B) is a single-pass transmembrane protein that is thought to be a novel risk factor for frontotemporal lobar degeneration (FTLD), a group of clinically, pathologically and genetically heterogeneous disorders associated with atrophy in the frontal lobe and temporal lobe of the brain. The actual role of TMEM106B, and that of the closely related protein TMEM106A are still undetermined.


Van Deerlin VM, Sleiman PM, Martinez-Lage M, et al. Common variants at 7p21 are associated with frontotemporal lobar degeneration with TDP-43 inclusions. Nat. Genet. 2010; 42:234-9.
Aswathy PM, Jairani PS, and Mathuranath PS. Genetics of frontotemporal lobar degeneration. Ann. Indian Acad. Neurol. 2010; 13(Suppl 2):S55-62.

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$ 310.00
Cat# ASC11462
(40 western blots)
Availability: 5-7days
Bulk Size
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