|Application ||WB, IHC-P, IF, E|
|Other Accession||NP_060844, 40254893|
|Calculated MW||Predicted: 30 kDa |
Observed: 33 kDa
|Application Notes||TMEM106B antibody can be used for detection of TMEM106B by Western blot at 1 µg/mL. Antibody can also be used for immunohistochemistry starting at 2.5 µg/mL. For immunofluorescence start at 2.5 µg/mL.|
|Target/Specificity||TMEM106B; This TMEM106B antibody is predicted to have no cross-reactivity to TMEM106A.|
|Reconstitution & Storage||TMEM106B antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.|
|Precautions||TMEM106B Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Involved in dendrite morphogenesis and maintenance by regulating lysosomal trafficking via its interaction with MAP6. May act by inhibiting retrograde transport of lysosomes along dendrites. Required for dendrite branching.|
|Cellular Location||Late endosome membrane; Single-pass type II membrane protein. Lysosome membrane; Single-pass type II membrane protein|
|Tissue Location||Expressed in frontal cortex.|
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Provided below are standard protocols that you may find useful for product applications.
TMEM106B Antibody: Transmembrane protein 106B (TMEM106B) is a single-pass transmembrane protein that is thought to be a novel risk factor for frontotemporal lobar degeneration (FTLD), a group of clinically, pathologically and genetically heterogeneous disorders associated with atrophy in the frontal lobe and temporal lobe of the brain. The actual role of TMEM106B, and that of the closely related protein TMEM106A are still undetermined.
Van Deerlin VM, Sleiman PM, Martinez-Lage M, et al. Common variants at 7p21 are associated with frontotemporal lobar degeneration with TDP-43 inclusions. Nat. Genet. 2010; 42:234-9.
Aswathy PM, Jairani PS, and Mathuranath PS. Genetics of frontotemporal lobar degeneration. Ann. Indian Acad. Neurol. 2010; 13(Suppl 2):S55-62.
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