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HHATL Antibody

  • WB - HHATL Antibody ASC11464
    Western blot analysis of HHATL in 3T3 cell lysate with HHATL antibody at 1 µg/mL.
  • IHC - HHATL Antibody ASC11464
    Immunohistochemistry of HHATL in human skin tissue with HHATL antibody at 2.5 µg/mL.
  • IF - HHATL Antibody ASC11464
    Immunofluorescence of HHATL in human skin tissue with HHATL antibody at 20 µg/mL.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9HCP6
Other Accession NP_065758, 239582769
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW 56703 Da
Application Notes HHATL antibody can be used for detection of HHATL by Western blot at 1 µg/mL. Antibody can also be used for immunohistochemistry starting at 2.5 µg/mL. For immunofluorescence start at 2.5 µg/mL.
Additional Information
Gene ID 57467
Target/Specificity HHATL;
Reconstitution & Storage HHATL antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
PrecautionsHHATL Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms C3orf3, GUP1, KIAA1173
Function Negatively regulates N-terminal palmitoylation of SHH by HHAT/SKN.
Cellular Location Endoplasmic reticulum membrane; Multi-pass membrane protein
Tissue Location Heart-specific..
Research Areas
Citations (0)

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HHATL Antibody: The Protein-cysteine N-palmitoyltransferase HHAT-like protein (HHATL), also known at the mammalian glycerol uptake/transporter 1 (Gup1) is a homolog of the S. cerevisiae Gup1. It is an endoplasmic reticulum (ER) membrane protein that co-localizes with the mammalian hedgehog acyltransferse Skn and interferes with its N-terminal palmitoylation of Sonic hedgehog (SHH), suggesting that HHATL acts as a negative regulator for N-terminal palmitoylation of SHH. HHATL is highly expressed in normal skin, but becomes down-regulated in skin squamous cell carcinoma, suggesting it may play a role in its development.


Abe Y, Kita Y, and Niikura T. Mammalian Gup1, a homolog of Saccharomyces cerevisiae glycerol uptake/transporter 1, acts as a negative regulator for N-palmitoylation of Sonic hedgehog. FEBS J. 2008; 275:318-31.
Zhang SQ, Tian X, Luo YW, et al. Expression, clinical and pathological significance of KIAA1173 gene in skin squamous cell carcinoma. Zhonghua Yi Xue Za Zhi 2010; 90:1243-6.

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$ 310.00
Cat# ASC11464
Availability: 5-7days
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