|Application ||WB, IHC-P, IF, E|
|Other Accession||NP_659495, 21450828|
|Calculated MW||23986 Da|
|Application Notes||RLP2 antibody can be used for detection of RLP2 by Western blot at 1 - 2 µg/mL. Antibody can also be used for immunohistochemistry starting at 2.5 µg/mL. For immunofluorescence start at 2.5 µg/mL.|
|Reconstitution & Storage||RLP2 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.|
|Precautions||RLP2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Involved in cell shape and neuronal morphogenesis, positively regulating the establishment and maintenance of dendritic spines. Plays a role in cellular protein transport, including protein transport away from primary cilia. May function via activation of RAC1 and PAK1 (By similarity).|
|Cellular Location||Cytoplasm, cytosol. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cell projection, cilium|
|Tissue Location||Widely expressed. Expressed at higher level in lung.|
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Provided below are standard protocols that you may find useful for product applications.
RLP2 Antibody: The Rab interacting lysosomal protein-like 2 (RLP2) protein is related to the is lysosomal protein RILP which interacts with RAB7, a small GTPase that controls transport to endocytic degradative compartments. Little is known of the exact function of RLP2, but it is thought that RILP is a downstream effector of RAB7 and both proteins act together in the regulation of late endocytic traffic, suggesting that RLP2 may be involved in endocytic traffic with RILP or play a similar role. RILP and possible RLP2 may also play a role in the biogenesis of multivesicular bodies.
Wang T, Wong KK, and Hong W. A unique region of RILP distinguishes it from its related proteins in its regulation of lysosomal morphology and interaction with Rab7 and Rab34. Mol. Biol. Cell 2004; 15:815-26.
Cantalupo G, Alifano P, Roberti V, et al. Rab-interacting lysosomal protein (RILP): the Rab7 effector required for transport to lysosomes. EMBO J. 2001; 20:683-93.
Progida C, Spinosa MR, De Luca A, et al. RILP interacts with the VPS22 component of the ESCRT-II complex. Biochem. Biophys. Res. Commun. 2006; 347:1074-9.
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