ZFX Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P, IF, E |
---|---|
Primary Accession | P17010 |
Other Accession | NP_003401, 71061446 |
Reactivity | Human, Mouse, Rat |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | IgG |
Calculated MW | 90522 Da |
Application Notes | ZFX antibody can be used for detection of ZFX by Western blot at 1 µg/mL. Antibody can also be used for immunohistochemistry starting at 5 µg/mL. For immunofluorescence start at 5 µg/mL. |
Gene ID | 7543 |
---|---|
Target/Specificity | ZFX; ZFX antibody is human specific. Multiple isoforms of ZFX are known to exist.. |
Reconstitution & Storage | ZFX antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. |
Precautions | ZFX Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | ZFX |
---|---|
Function | Probable transcriptional activator. |
Cellular Location | Nucleus. |
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Provided below are standard protocols that you may find useful for product applications.
Background
ZFX Antibody: The X-linked zinc finger protein ZFX is a member of the Kruppel C2H2-type zinc-finger protein family. The full-length protein contains an acidic transcriptional activation domain (AD), a nuclear localization sequence (NLS) and a DNA binding domain (DBD) consisting of 13 C2H2-type zinc fingers. Studies in mouse embryonic and adult hematopoietic stem cells showed that this gene was required as a transcriptional regulator for self-renewal of both stem cell types, but it was dispensable for growth and differentiation of their progeny.
References
Schneider-Gadicke A, Beer-Romero P, Brown LG, et al. Putative transcription activator with alternative isoforms encoded by human ZFX gene. Nature 1989; 342:708-11.
Galan-Caridad JM, Harel S, Arenzana TL, et al. Zfx controls the self-renewal of embryonic and hematopoietic stem cells. Cell 2007; 129:345-57.
Arenzana TL, Smith-Raska MR, and Reizis B. Transcription factor Zfx controls BCR-induced proliferation and survival of B lymphocytes. Blood 2009; 113:5857-67
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