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THBS4 Antibody

  • WB - THBS4 Antibody ASC11484
    Western blot analysis of THBS4 in mouse lung tissue lysate with THBS4 antibody at (A) 1 and (B) 2 µg/mL.
  • IF - THBS4 Antibody ASC11484
    Immunofluorescence of THBS4 in human lung cells with THBS4 antibody at 20 µg/mL.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P35443
Other Accession NP_003239, 31543806
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW 105869 Da
Application Notes THBS4 antibody can be used for detection of THBS4 by Western blot at 1 - 2 µg/mL. Antibody can also be used for immunofluorescence starting at 20 µg/mL. For immunofluorescence start at 5 µg/mL.
Additional Information
Gene ID 7060
Target/Specificity THBS4; At least two isoforms of THBS4 are known to exist; this antibody will only detect the longer isoform.
Reconstitution & Storage THBS4 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
PrecautionsTHBS4 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name THBS4
Synonyms TSP4
Function Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions and is involved in various processes including cellular proliferation, migration, adhesion and attachment, inflammatory response to CNS injury, regulation of vascular inflammation and adaptive responses of the heart to pressure overload and in myocardial function and remodeling. Binds to structural extracellular matrix (ECM) proteins and modulates the ECM in response to tissue damage, contributing to cardioprotective and adaptive ECM remodeling. Plays a role in ER stress response, via its interaction with the activating transcription factor 6 alpha (ATF6) which produces adaptive ER stress response factors and protects myocardium from pressure overload. May contribute to spinal presynaptic hypersensitivity and neuropathic pain states after peripheral nerve injury. May play a role in regulating protective astrogenesis from the subventricular zone (SVZ) niche after injury in a NOTCH1-dependent manner (By similarity).
Cellular Location Endoplasmic reticulum. Sarcoplasmic reticulum. Secreted. Secreted, extracellular space. Secreted, extracellular space, extracellular matrix
Research Areas
Citations (0)

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THBS4 Antibody: Thrombospondin-4 (THBS4) belongs to the thrombospondin protein family, a family of adhesive calcium-binding glycoproteins that mediate cell-to-cell and cell-to-matrix interactions. Studies suggest that this protein may be involved in local signaling in the developing and adult nervous system. THBS4 is widely expressed and is abundant in atherosclerotic lesions and in areas prone to the development of lesions. It has been suggested to play an important role in the recruitment of macrophages and the local regulation of inflammation associated with atherogenesis. THBS4 has also been suggested as a putative tumor-suppressor protein in colorectal cancer.


Arber S and Caroni P. Thrombospondin-4, an extracellular matrix protein expressed in the developing and adult nervous system promotes neurite outgrowth. J. Cell Biol. 1995; 131:1083-94
Adams JC and Lawler J. The thrombospondins. Int. J. Biochem. Cell Biol. 2004; 36:961-8.
Frolova EG, Pluskota E, Krukovets I, et al. Thrombospondin-4 regulates vascular inflammation and atherogenesis. Circ. Res. 2010; 107:1313-25.
Greco SA, Chia J, Inglis KJ, et al. Thrombospondin-4 is a putative tumour-suppressor gene in colorectal cancer that exhibits age-related methylation. BMC Cancer 2010; 10:494.

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$ 310.00
Cat# ASC11484
(40 western blots)
Availability: 5-7days
Bulk Size
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