|Application ||WB, IF, E|
|Other Accession||NP_055588, 217330656|
|Calculated MW||55920 Da|
|Application Notes||DELE antibody can be used for detection of DELE by Western blot at 1 µg/mL. For immunofluorescence start at 20 µg/mL.|
|Reconstitution & Storage||DELE antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.|
|Precautions||DELE Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Essential for the induction of death receptor-mediated apoptosis through the regulation of caspase activation.|
|Tissue Location||Detected in liver, skeletal muscle, kidney, pancreas, spleen, thyroid, testis, ovary, small intestine and colon.|
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Provided below are standard protocols that you may find useful for product applications.
DELE Antibody: DELE is a recently identified DAP3-binding protein that is thought to be important in the induction of death receptor-mediated apoptosis. Transfected cells that stably express DELE were found to be susceptible to apoptosis induction by TNF-α and TRAIL, whereas reducing DELE expression by siRNA rescued these cells from apoptosis induction. Furthermore, the reduction of DELE expression also inhibited the activation of caspase-3, caspase-8 and caspase-9 following stimulation by TNF-α, anti-Fas, or TRAIL, indicating the importance of DELE in apoptosis mediated by death receptors.
Harada T, Iwai A, Miyazaki T. Identification of DELE, a novel DAP-binding protein which is crucial for death receptor-mediated apoptosis induction. Apoptosis 2010; 15:1247-55.
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