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>   home   >   Products   >   Primary Antibodies   >   Cell Biology   >   FAM193B Antibody   

FAM193B Antibody

  • WB - FAM193B Antibody ASC11512
    Western blot analysis of FAM193B in Jurkat cell lysate with FAM193B antibody at 1 µg/mL in (A) the absence and (B) the presence of blocking peptide.
  • IF - FAM193B Antibody ASC11512
    Immunofluorescence of FAM193B in Jurkat cells with FAM193B antibody at 20 µg/mL.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q96PV7
Other Accession Q96PV7, 205831282
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW 99 kDa
Application Notes FAM193B antibody can be used for detection of FAM193B by Western blot at 1 µg/mL. For immunofluorescence start at 20 µg/mL.
Additional Information
Gene ID 54540
Target/Specificity FAM193B; At least two isoforms of FAM193B are known to exist; this antibody will detect both isoforms.
Reconstitution & Storage FAM193B antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
PrecautionsFAM193B Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name FAM193B
Synonyms IRIZIO, KIAA1931
Cellular Location Cytoplasm. Nucleus. Note=Partly colocalized with an endoplasmic reticulum marker, HSP90B1. Shuttles between nucleus and cytoplasm
Tissue Location Isoform 1 is up-regulated in both embryonal rhabdomyosarcoma and alveolar rhabdomyosarcoma cell lines
Research Areas
Citations (0)

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FAM193B Antibody: FAM193B, also known as IRIZIO, was initially identified as a protein that is upregulated in alveolar rhabdomyosarcoma (ARMS), a type of fast-growing tumor characterized by chromosomal translocations fusing the PAX3 or PAX7 gene with that of FOXO1. It has been suggested that, in addition to the PAX3-FOXO1 gene fusion, disruption of the Rb and p53 pathways is required for full ARMS tumorigenesis. In PAX3-FOXO1-expressing primary mouse fibroblasts that possessed a defective p53 pathway, FAM193B expression enabled the tumorigenic transformation, suggesting that FAM193B may contribute to rhabdomyosarcomagenesis in humans.


Picchione F, Pritchard C, Lagutina I, et al. IRIZIO: a novel gene cooperating with PAX3-FOXO1 in alveolar rhabdomyosarcoma (ARMS). Carcinogenesis 2011; 32:452-62.
Linardic CM. PAX3-FOXO1 fusion gene in rhabdomyosarcoma. Cancer Lett. 2008; 270:10-8.

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$ 330.00
Cat# ASC11512
Availability: 5-7days
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