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CLEC2A Antibody

  • WB - CLEC2A Antibody ASC11520
    Western blot analysis of CLEC2A in K562 cell lysate with CLEC2A antibody at 1 µg/ml in (A) the absence and (B) the presence of blocking peptide.
  • IF - CLEC2A Antibody ASC11520
    Immunofluorescence of CLEC2A in K562 cells with CLEC2A antibody at 20 µg/mL.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q6UVW9
Other Accession NP_001124183, 195222725
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW 19972 Da
Application Notes CLEC2A antibody can be used for detection of CLEC2A by Western blot at 1 µg/mL. For immunofluorescence start at 20 µg/mL.
Additional Information
Gene ID 387836
Target/Specificity CLEC2A; CLEC2A antibody is human specific. Two alternatively spliced transcript variants have been observed.
Reconstitution & Storage CLEC2A antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
PrecautionsCLEC2A Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms KACL
Function Plays a role in modulating the extent of T-cell expansion. Enhances the expansion of TCR-stimulated T-cells by increasing their survival through enhanced expression of anti- apoptotic proteins. May modulate the capacity of T-cells to home to lymph nodes through SELL. Facilitates dedicated immune recognition of keratinocytes via interaction with its receptor KLRF2 by stimulating natural killer cell mediated cytotoxicity.
Cellular Location Cell membrane; Single-pass type II membrane protein
Tissue Location Mainly expressed in skin. Also expressed in keratinocytes, spleen, thymus, small intestine, peripheral blood monocytes, bone marrow, ovary, testis and skin. High expression in CD8(+), B-lymphocytes and naive CD4(+) T-cells. Restricted mostly to proliferating lymphocytes. Not detected in myeloid leukocytes or natural killer (NK) cells.
Research Areas
Citations (0)

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CLEC2A Antibody: CLEC2A (C-type lectin domain family 2 member A), also known as PILAR (proliferation-induced lymphocyte-associated receptor) is involved in modulating T-cell expansion. It is a 32 kDa single-pass type II membrane protein that contains one C-type lectin domain in its extracellular region and belongs to the CTL/CTLD superfamily. CLEC2A is mainly expressed in skin and highly expressed in CD8(+), B lymphocytes and naive CD4(+) T cells. Manipulation of CLEC2A signaling may be important for treatment of autoimmune diseases and cancer.


Huarte E, Cubillos-Ruiz JR, Nesbeth YC, et al. PILAR is a novel modulator of human T-cell expansion. Blood 2008; 112:1259-68.
Drickamer K. C-type lectin-like domains. Curr. Opin. Struct. Biol. 1999; 9:585-90
Spreu J, Kienle EC, Schrage B, et al. CLEC2A: a novel, alternatively spliced and skin-associated member of the NKC-encoded AICL-CD69-LLT1 family. Immunogenetics 2007; 59:903-12.
Spreu J, Kuttruff S, Stejfova V, et al. Interaction of C-type lectin-like receptors NKp65 and KACL facilitates dedicated immune recognition of human keratinocytes. Proc. Natl. Acad. Sci. USA 2010; 107:5100-5.

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$ 310.00
Cat# ASC11520
(40 western blots)
Availability: 5-7days
Bulk Size
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