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TCIRG1 Antibody

  • WB - TCIRG1 Antibody ASC11523
    Western blot analysis of TCIRG1 in EL4 cell lysate with TCIRG1 antibody at 0.5 µg/ml in (A) the absence and (B) the presence of blocking peptide.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q13488
Other Accession NP_006010, 19924145
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW 91 kDa
Application Notes TCIRG1 antibody can be used for detection of TCIRG1 by Western blot at 0.5 µg/mL.
Additional Information
Gene ID 10312
Target/Specificity TCIRG1; At least two alternatively spliced isoforms are known to exist; this antibody will only detect the larger isoform.
Reconstitution & Storage TCIRG1 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
PrecautionsTCIRG1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms ATP6N1C, ATP6V0A3
Function Part of the proton channel of V-ATPases (By similarity). Seems to be directly involved in T-cell activation.
Cellular Location Membrane; Multi-pass membrane protein
Tissue Location Isoform long is highly expressed in osteoclastomas. Isoform short is highly expressed in thymus
Research Areas
Citations (0)

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TCIRG1 Antibody: The T-cell immune regulator 1 (TCIRG1) is the a3 subunit of the vacuolar-type proton transporting ATPase (V-ATPase), a proton pump in late endosomes and lysosomes that functions in the luminal acidification of these organelles. Genetic defects in the gene encoding this protein a responsible for a severe form of autosomal recessive osteopetrosis, a condition that leads to increased bone density, decreased bone strength, and inflammation in bone tissues. TCIRG1 is also required for the normal secretion of insulin and the bacteria-killing function of macrophages.


Toyomura T, Oka T, Yamaguchi C, et al. Three subunit a isoforms of mouse vacuolar H+-ATPase. Preferential expression of the a3 isoform during osteoclast differentiation. J. Biol. Chem. 2000; 275:8760-5
Kornak U, Schulz A, Friedrich W, et al. Mutations in the a3 subunit of the vacuolar H+-ATPase cause malignant osteopetrosis. Hum. Mol. Genet. 2000; 9:2059-63.
Sun-Wada GH, Toyomura T, Kawamura N, et al. The a3 isoform of V-ATPase regulates insulin secretion from pancreatic b-cells. J. Cell Sci. 2006; 119:4531-40.
Sun-Wada GH, Tabata H, Kawamura N, et al. Direct recruitment of H+-ATPase from lysosomes for phagocytic acidification. J. Cell Sci. 2009; 122:2504-13.

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$ 310.00
Cat# ASC11523
(40 western blots)
Availability: 5-7days
Bulk Size
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