|Application ||WB, IF, E|
|Other Accession||CAQ08933, 168985143|
|Calculated MW||82 kDa|
|Application Notes||SGSM3 antibody can be used for detection of SGSM3 by Western blot at 1 µg/mL. For immunofluorescence start at 20 µg/mL.|
|Target/Specificity||SGSM3; Multiple isoforms of SGSM3 are known to exist. SGSM3 antibody is predicted to not cross react with other SGSM family proteins.|
|Reconstitution & Storage||SGSM3 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.|
|Precautions||SGSM3 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May play a cooperative role in NF2-mediated growth suppression of cells.|
|Tissue Location||Widely expressed.|
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Provided below are standard protocols that you may find useful for product applications.
SGSM3 Antibody: Small G proteins such as RAP and RAB proteins are the key molecules in intracellular signal transduction and vesicle transportation. A novel protein family small G protein signaling modulator (SGSM) consisting of three members SGSM1-3 bind to RAP and RAB family proteins. All three SGSM proteins possess both a RUN domain and a TBC domain. Little is known of the exact function of SGSM3.
Bar-Sagi D and Hall A. Ras and Rho GTPases: a family reunion. Cell 2000; 103:227-38.
Colicelli J. Human ras superfamily proteins and related GTPases. Sci. STKE 2004; 250:RE13.
Yang H, Sasaki T, Minoshima S, et al. Identification of three novel proteins (SGSM1, 2, 3) which modulate small G protein (RAP and RAB)-mediated signaling pathway. Genomics 2007; 90:249-60.
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