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DCP2 Antibody

  • WB - DCP2 Antibody ASC11553
    Western blot analysis of DCP2 in 293 cell lysate with DCP2 antibody at 1 µg/mL in (A) the absence and (B) the presence of blocking peptide.
  • IF - DCP2 Antibody ASC11553
    Immunofluorescence of DCP2 in human testis tissue with DCP2 antibody at 20 µg/mL.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q8IU60
Other Accession NP_689837, 31542498
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW 46 kDa
Application Notes DCP2 antibody can be used for detection of DCP2 by Western blot at 1 µg/mL. For immunofluorescence start at 20 µg/mL.
Additional Information
Gene ID 167227
Target/Specificity DCP2; Multiple isoforms of DCP2 are known to exist.
Reconstitution & Storage DCP2 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
PrecautionsDCP2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name DCP2
Synonyms NUDT20
Function Decapping metalloenzyme that catalyzes the cleavage of the cap structure on mRNAs. Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP. Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Plays a role in replication-dependent histone mRNA degradation. Has higher activity towards mRNAs that lack a poly(A) tail. Has no activity towards a cap structure lacking an RNA moiety.
Cellular Location Cytoplasm, P-body. Nucleus. Note=Predominantly cytoplasmic, in processing bodies (PB). A minor amount is nuclear
Tissue Location Expressed in brain and testis. Not detected in heart (at protein level).
Citations (0)

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DCP2 Antibody: The removal, or decapping, of eukaryotic mRNA is an important step in the degradation of mRNA. Decapping protein 2 (DCP2) is the major mRNA decapping enzyme in cells. It is a member of the Nudix hydrolases superfamily of proteins that predominantly catalyze the hydrolysis of small nucleoside diphosphate substrates linked to another moiety. DCP2 is widely expressed in multiple tissues at varying levels, with highest expression seen in testis and brain.


Song MG, Li Y, and Kiledjian M. Multiple mRNA decapping enzymes in mammalian cells. Mol. Cell 2010; 40:423-32.
Dunckley T and Parker R. The DCP2 protein is required for mRNA decapping in Saccharomyces cerevisiae and contains a functional MutT motif. EMBO J. 18:5411-22.
Bessman MJ, Frick DN, and O’Handley SF. The MutT proteins of “Nudix" hydrolases, a family of versatile, widely distributed, “housecleaning" enzymes. J. Biol. Chem. 1996; 271:25059-62

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$ 310.00
Cat# ASC11553
(40 western blots)
Availability: 5-7days
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