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PANX1 Antibody

  • WB - PANX1 Antibody ASC11574
    Western blot analysis of PANX1 in human ovary tissue lysate with PANX1 antibody at 1 µg/mL.
  • IF - PANX1 Antibody ASC11574
    Immunofluorescence of PANX1 in human ovary tissue with PANX1 antibody at 20 µg/mL.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q96RD7
Other Accession NP_056183, 39995064
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW 47 kDa
Application Notes PANX1 antibody can be used for detection of PANX1 by Western blot at 1 - 2 µg/mL. For immunofluorescence start at 20 µg/mL.
Additional Information
Gene ID 24145
Target/Specificity PANX1; Two transcript variants encoding different isoforms have been found for this gene.
Reconstitution & Storage PANX1 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
PrecautionsPANX1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PANX1
Synonyms MRS1
Function Structural component of the gap junctions and the hemichannels. May play a role as a Ca(2+)-leak channel to regulate ER Ca(2+) homeostasis.
Cellular Location Cell membrane; Multi-pass membrane protein {ECO:0000255|PROSITE-ProRule:PRU00351}. Cell junction, gap junction. Endoplasmic reticulum membrane; Multi-pass membrane protein {ECO:0000255|PROSITE- ProRule:PRU00351}
Research Areas
Citations (0)

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PANX1 Antibody: The pannexin gene family encodes a second class of putative gap junction proteins and are highly conserved in invertebrates and mammals. Pannexins (Panx) are four-pass transmembrane proteins that oligomerize to form large pore ion and metabolite-permeable channels. Pannexin-1 (PANX1) and Pannexin-3 are closely related, while Pannexin-2 is a more distant relation. PANX1 is a transmembrane protein that forms a mechanosensitive ATP-permeable channel between adjacent cells and in the endoplasmic reticulum. PANX1 may play a role as a Ca2+ -leak channel to regulate ER Ca2+ homeostasis and regulates neural stem and progenitor cell proliferation.


Barbe MT, Monyer H and Bruzzone R. Cell-cell communication beyond connexins: the pannexin channels. Physiology 2006; 21:103-14.
Baranova A, Ivanov D, Petrash N, et al. The mammalian pannexin family is homologous to the invertebrate innexin gap junction proteins. Genomics 2004; 83:706-16.
Sohl G, Maxeiner S and Willecke K. Expression and functions of neuronal gap junctions. Nat. Rev. Neurosci. 2005; 6:191-200
Bao L, Locovei S and Dahl G. Pannexin membrane channels are mechanosensitive conduits for ATP. FEBS Lett. 2004; 572:65-8.

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$ 310.00
Cat# ASC11574
(40 western blots)
Availability: 5-7days
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