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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   SHROOM1 Antibody   

SHROOM1 Antibody

  • WB - SHROOM1 Antibody ASC11580
    Western blot analysis of SHROOM1 in mouse heart tissue lysate with SHROOM1 antibody at 1 µg/mL in (A) the absence and (B) the presence of blocking peptide.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q2M3G4
Other Accession NP_001166171, 289577098
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW 94 kDa
Application Notes SHROOM1 antibody can be used for detection of SHROOM1 by Western blot at 1 - 2 µg/mL.
Additional Information
Gene ID 134549
Target/Specificity SHROOM1; SHROOM1 antibody is human, mouse and rat reactive. At least three isoforms of SHROOM1 are known to exist; this antibody will detect only the two largest isoforms. SHROOM1 antibody is predicted to not cross-react with other SHROOM family members.
Reconstitution & Storage SHROOM1 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
PrecautionsSHROOM1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms APXL2, KIAA1960
Function May be involved in the assembly of microtubule arrays during cell elongation.
Cellular Location Cytoplasm, cytoskeleton.
Research Areas
Citations (0)

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SHROOM1 Antibody: SHROOM family members play diverse roles in the development of the nervous system and other tissues. SHROOM1 is a PDZ domain-containing actin-binding protein that is required for neural tube morphogenesis. It facilitates neurulation by regulating the morphology of neurepithelial cells via the apical positioning of an actomyosin network in the neurepithelium. SHROOM1 is also expressed in pulmonary arterial smooth muscle cells and its expression is significantly decreased in mouse and human models of pulmonary arterial hypertension, suggesting that there may be a link between SHROOM1 expression and pulmonary arterial hypertension.


Lee C, Le MP, and Wallingford JB. The shroom family proteins play broad roles in the morphogenesis of thickened epithelial sheets. Dev. Dyn. 2009; 238:1480-91.
Hildebrand JD and Soriano P. Shroom, a PDZ domain-containing actin-binding protein, is required for neural tube morphogenesis in mice. Cell 1999; 99:486-97
Hildebrand JD. Shroom regulates epithelial cell shape via the apical positioning of an actomyosin network. J. Cell Sci. 2005; 118:5191-203.
Sevilla-Perez J, Konigshoff M, Kwapiszewska G, et al. Shroom expression is attenuated in pulmonary arterial hypertension. Eur. Respir. J. 2008; 32:871-880.

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$ 310.00
Cat# ASC11580
(40 western blots)
Availability: 5-7days
Bulk Size
Seasonal Special on Bulk Order
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