|Application ||WB, E|
|Other Accession||NP_001184171, 308522758|
|Calculated MW||32 kDa|
|Application Notes||TSPY1S antibody can be used for detection of TSPY1S by Western blot at 1 - 2 µg/mL.|
|Target/Specificity||TSPY1; TSPY1S antibody is human and mouse reactive. At least three isoforms of TSPY1 are known to exist; this antibody will detect only TSPY1S|
|Reconstitution & Storage||TSPY1S antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.|
|Precautions||TSPY1S Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May be involved in sperm differentiation and proliferation.|
|Cellular Location||Cytoplasm. Nucleus. Note=Predominantly cytoplasmic. Also found in nucleus|
|Tissue Location||Specifically expressed in testicular tissues. Isoform 1 and isoform 2 are expressed in spermatogonia and spermatocytes. Found in early testicular carcinoma in situ, spermatogonial cells in testicular tissues of 46,X,Y female and in prostate cancer cell lines.|
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Provided below are standard protocols that you may find useful for product applications.
TSPY1S Antibody: Testis-specific protein on Y chromosome (TSPY1) is an ampliconic gene on the Y chromosome that has been associated with gonadoblastoma. Recent experiments have shown that in androgen-dependent testicular germ-cell tumors, TSPY1 can repress the androgen-bound androgen receptor (AR), a member of the nuclear steroid hormone receptor family that acts as a ligand-inducible transcription factor, suggesting that TSPY1 is a repressor of cell proliferation in germ-cell tumors and potentially in normal gonadal cells during early development. Two distinct isoforms of TSPY1, TSPY1L and TSPY1S, are known to exist.
Arnemann J, Jakubiczka S, Thuring S, et al. Cloning and sequence analysis of a human Y-chromosome-derived, testicular cDNA, TSPY. Genomics 1991; 11:108-114
Lau YF. Gonadoblastoma, testicular and prostate cancers, and the TSPY gene. Am. J. Hum. Genet. 1999; 64:921-7.
Akimoto C, Ueda T, Inoue K, et al. Testis-specific protein on Y chromosome (TSPY) represses the activity of the androgen receptor in androgen-dependent testicular germ-cell tumors. Proc. Natl. Acad. Sci. USA 2010; 107:19891-6.
Krick R, Jacubiczka S, and Arnemann J. Expression, alternative splicing and haplotype analysis of transcribed testis specific protein (TSPY) genes. Gene 2003; 302:11-9.
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