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>   home   >   Products   >   Primary Antibodies   >   Cell Biology   >   CHCHD6 Antibody   

CHCHD6 Antibody

  • WB - CHCHD6 Antibody ASC11584
    Western blot analysis of CHCHD6 in SK-N-SH cell lysate with CHCHD6 antibody at 1 µg/mL.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9BRQ6
Other Accession NP_115719, 14150134
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW Predicted: 26 kDa
Application Notes CHCHD6 antibody can be used for detection of CHCHD6 by Western blot at 1 - 2 µg/mL.
Additional Information
Gene ID 84303
Target/Specificity CHCHD6; CHCHD6 is predicted to not cross-react to other members of the CHCHD family.
Reconstitution & Storage CHCHD6 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year.
PrecautionsCHCHD6 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms CHCM1, MIC25
Function Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.
Cellular Location Mitochondrion inner membrane; Lipid-anchor
Research Areas
Citations (0)

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CHCHD6 Antibody: CHCHD6 is a member of a family of proteins containing a conserved (coiled coil 1)-(helix 1)-(coiled coil 2)-(helix 2) domain and has been observed in a complex with the mitochondrial proteins mitofilin, SAM50, metaxins 1 and 2, and CHCHD3. CHCHD6 knockdown causes severe defects in mitochondrial cristae morphology as well as reductions in cell growth, ATP production and oxygen consumption. This decrease of CHCHD6 also led to a reduction in mitofilin protein levels, while a knockdown of mitofilin resulted in a reduced level of CHCHD6, suggesting coordinate regulation between these two proteins. CHCHD6 knockdown in human cancer cells enhances their sensitivity to genotoxic anticancer drugs, suggesting that CHCHD6 may be a potential therapeutic anti-tumor target.


Xie J, Marusich MF, Souda P, et al. The mitochondrial inner membrane protein Mitofilin exists as a complex with SAM50, metaxins 1 and 2, coiled-coil-helix coiled-coil-helix domain-containing protein 3 and 6 and DnaJC11. FEBS Lett. 2007; 581:3545-9.
An J, Shi J, He Q, et al. CHCM1/CHCHD6, novel mitochondrial protein linked to regulation of mitofilin and mitochondrial cristae morphology. J. Biol. Chem. 2012; 287:7411-26.

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$ 310.00
Cat# ASC11584
(40 western blots)
Availability: 5-7days
Bulk Size
Seasonal Special on Bulk Order
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