|Application ||WB, E|
|Other Accession||NP_077276, 64464338|
|Reactivity||Human, Mouse, Rat|
|Calculated MW||Predicted: 11 kDa|
|Application Notes||CHCHD7 antibody can be used for detection of CHCHD7 by Western blot at 1 - 2 µg/mL.|
|Target/Specificity||CHCHD7; Three alternatively spliced transcript variants have been observed. CHCHD7 is predicted to not cross-react to other members of the CHCHD family.|
|Reconstitution & Storage||CHCHD7 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year.|
|Precautions||CHCHD7 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Cellular Location||Mitochondrion intermembrane space|
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Provided below are standard protocols that you may find useful for product applications.
CHCHD7 Antibody: CHCHD7 is a newly identified member of a multifamily of proteins containing a conserved (coiled coil 1)-(helix 1)-(coiled coil 2)-(helix 2) domain. Northern blot analysis revealed that the gene is ubiquitously expressed. Its biological function is unknown and the gene has hitherto not been associated with neoplasia. CHCHD7 and PLAG1 are located head-to-head about 500 bp apart in 8q12. A chromosomal aberration involving CHCHD7 is found in salivary gland pleiomorphic adenomas, the most common benign epithelial tumors of the salivary gland.
Asp J, Persson F, Kost-Alimova M, et al. CHCHD7-PLAG1 and TCEA1-PLAG1 gene fusions resulting from cryptic, intrachromosomal 8q rearrangements in pleomorphic salivary gland adenomas. Genes Chromosomes Cancer 2006; 45:820-8.
Nishimura S, Watanabe T, Mizoshita K, et al. Genome-wide association study identified three major QTL for carcass weight including the PLAG1-CHCHD7 QTN for stature in Japanese Black cattle. BMC Genet. 2012; 13:40.
Matsuyama A, Hisaoka M, and Hashimoto H. PLAG1 expression in cutaneous mixed tumors: an immunohistochemical and molecular genetic study. Virchows Arch. 2011; 459:539-45.
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