|Application ||WB, E|
|Other Accession||NP_848665, 30425563|
|Calculated MW||Predicted: 46 kDa|
|Application Notes||RTN4RL2 antibody can be used for detection of RTN4RL2 by Western blot at 1 - 2 µg/mL.|
|Target/Specificity||RTN4RL2; Three alternatively spliced transcript variants have been observed. RTN4RL2 antibody is predicted to not cross-react with other Nogo receptor-like proteins.|
|Reconstitution & Storage||RTN4RL2 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year.|
|Precautions||RTN4RL2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May play a role in regulating axonal regeneration and plasticity in the adult central nervous system.|
|Cellular Location||Cell membrane; Lipid-anchor, GPI-anchor Note=Localized to the surface of neurons, including axons|
|Tissue Location||Highly expressed in brain and liver. Expressed at lower levels in kidney, mammary gland, placenta, skeletal muscle, spleen and thyroid.|
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Provided below are standard protocols that you may find useful for product applications.
RTN4RL2 Antibody: Reticulon 4 receptor-like 2 (RTN4RL2), also known as NgR2and NgRH1, is a 60 kDa glycosylphosphatidylinositol-anchored protein that is expressed primarily in the brain. It contains eight leucine-rich repeats that are flanked by cysteine-rich sequences at both the N- and C-termini. The membrane anchored RTN4RL2 can be solubilized through the action of phospholipase or an unidentified MTMMP to generate a 46 kDa soluble receptor. It has been suggested that RTN4RL2 may play a role in regulating axonal regeneration and plasticity in the adult central nervous system.
Pignot V, Hein AE, Barske C, et al. Characterization of two novel proteins, NgRH1 and NgRH2, structurally and biochemically homologous to the Nogo-66 receptor. J. Neurochem. 2003; 85:717-28.
Venkatesh K, Chivatakam O, Lee H, et al. The Nogo-66 receptor homolog NgR2 is a sialic acid-dependent receptor selective for myelin-associated glycoprotein. J. Neurosci. 2005; 25:808-22.
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