|Application ||WB, E|
|Other Accession||NP_001009184, 57165375|
|Calculated MW||Predicted: 41 kDa|
|Application Notes||GRINA antibody can be used for detection of GRINA by Western blot at 1 - 2 µg/mL.|
|Target/Specificity||GRINA; GRINA antibody is predicted to not cross-react with other members of the TMBIM family.|
|Reconstitution & Storage||GRINA antibody can be stored at 4℃ for three months and -20℃, stable for up to one year.|
|Precautions||GRINA Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||LFG1, NMDARA1, TMBIM3|
|Function||Potential apoptotic regulator.|
|Cellular Location||Membrane; Multi-pass membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
GRINA Antibody: The transmembrane BAX inhibitor motif (TMBIM) family of proteins includes the founder member TMBIM6/BI-1, TMBIM1/RECS1 (responsive to centrifugal force and shear stress gene 1 protein), TMBIM2/LFG (life guard), TMBIM3/GRINA (glutamate receptor ionotropic NMDA protein 1), TMBIM4/GAAP (Golgi anti-apoptotic-associated protein), and TMBIM5/GHTIM (growth hormone-inducible transmembrane protein). They are highly conserved in mammals and zebrafish and contain a conserved BAX inhibitor-1 motif. GRINA is expressed in the brain and is a potential apoptotic regulator.
Yamaji T, Nishikawa K and Hanada K et al. Transmembrane BAX inhibitor motif containing (TMBIM) family proteins perturbs a trans-Golgi network enzyme, Gb3 synthase, and reduces Gb3 biosynthesis. J. Biol. Chem. 2010; 285:35505-18.
Nielsen JA, Chambers MA, Romm E, et al. Mouse transmembrane BAX inhibitor motif 3 (Tmbim3) encodes a 38 kDa transmembrane protein expressed in the central nervous system. Mol. Cell. Biochem. 2011; 357:73-81.
Rojas-Rivera D, Armisén R, Colombo A, et al. TMBIM3/GRINA is a novel unfolded protein response (UPR) target gene that controls apoptosis through the modulation of ER calcium homeostasis. Cell Death Differ. 2012; 19:1013-26.
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