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GRINA Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q7Z429 |
| Other Accession | NP_001009184, 57165375 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Calculated MW | Predicted: 41 kDa |
| Application Notes | GRINA antibody can be used for detection of GRINA by Western blot at 1 - 2 µg/mL. |
| Gene ID | 2907 |
|---|---|
| Target/Specificity | GRINA; GRINA antibody is predicted to not cross-react with other members of the TMBIM family. |
| Reconstitution & Storage | GRINA antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. |
| Precautions | GRINA Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | GRINA |
|---|---|
| Synonyms | LFG1, NMDARA1, TMBIM3 |
| Function | Potential apoptotic regulator. |
| Cellular Location | Membrane; Multi-pass membrane protein |
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Provided below are standard protocols that you may find useful for product applications.
Background
GRINA Antibody: The transmembrane BAX inhibitor motif (TMBIM) family of proteins includes the founder member TMBIM6/BI-1, TMBIM1/RECS1 (responsive to centrifugal force and shear stress gene 1 protein), TMBIM2/LFG (life guard), TMBIM3/GRINA (glutamate receptor ionotropic NMDA protein 1), TMBIM4/GAAP (Golgi anti-apoptotic-associated protein), and TMBIM5/GHTIM (growth hormone-inducible transmembrane protein). They are highly conserved in mammals and zebrafish and contain a conserved BAX inhibitor-1 motif. GRINA is expressed in the brain and is a potential apoptotic regulator.
References
Yamaji T, Nishikawa K and Hanada K et al. Transmembrane BAX inhibitor motif containing (TMBIM) family proteins perturbs a trans-Golgi network enzyme, Gb3 synthase, and reduces Gb3 biosynthesis. J. Biol. Chem. 2010; 285:35505-18.
Nielsen JA, Chambers MA, Romm E, et al. Mouse transmembrane BAX inhibitor motif 3 (Tmbim3) encodes a 38 kDa transmembrane protein expressed in the central nervous system. Mol. Cell. Biochem. 2011; 357:73-81.
Rojas-Rivera D, Armisén R, Colombo A, et al. TMBIM3/GRINA is a novel unfolded protein response (UPR) target gene that controls apoptosis through the modulation of ER calcium homeostasis. Cell Death Differ. 2012; 19:1013-26.
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