|Application ||WB, E|
|Other Accession||NP_003322, 187608615|
|Reactivity||Human, Mouse, Rat|
|Calculated MW||Predicted: 131 kDa|
|Application Notes||TYK2 antibody can be used for detection of TYK2 by Western blot at 1 - 2 µg/mL.|
|Target/Specificity||TYK2; At least three isoforms of TYK2 are known to exist; this antibody only detects the two longest isoforms.|
|Reconstitution & Storage||TYK2 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year.|
|Precautions||TYK2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Probably involved in intracellular signal transduction by being involved in the initiation of type I IFN signaling. Phosphorylates the interferon-alpha/beta receptor alpha chain.|
|Tissue Location||Observed in all cell lines analyzed. Expressed in a variety of lymphoid and non-lymphoid cell lines|
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Provided below are standard protocols that you may find useful for product applications.
TYK2 Antibody: TYK2 is a member of the Janus kinases (JAKs) protein families. TYK2 associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits and is also a component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulin E.
Strobl B, Stoiber D, Sexl V, et al. Tyrosine kinase 2 (TYK2) in cytokine signalling and host immunity. Front. Biosci. 2011; 17:3214-32.
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