|Application ||WB, E|
|Other Accession||NP_061113, 8924262|
|Calculated MW||Predicted: 26 kDa|
|Application Notes||TREM1 antibody can be used for detection of TREM1 by Western blot at 1 - 2 µg/mL.|
|Reconstitution & Storage||TREM1 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year.|
|Precautions||TREM1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Stimulates neutrophil and monocyte-mediated inflammatory responses. Triggers release of pro-inflammatory chemokines and cytokines, as well as increased surface expression of cell activation markers. Amplifier of inflammatory responses that are triggered by bacterial and fungal infections and is a crucial mediator of septic shock.|
|Cellular Location||Isoform 1: Cell membrane; Single-pass type I membrane protein|
|Tissue Location||Highly expressed in adult liver, lung and spleen than in corresponding fetal tissue. Also expressed in the lymph node, placenta, spinal cord and heart tissues. Expression is more elevated in peripheral blood leukocytes than in the bone marrow and in normal cells than malignant cells. Expressed at low levels in the early development of the hematopoietic system and in the promonocytic stage and at high levels in mature monocytes Strongly expressed in acute inflammatory lesions caused by bacteria and fungi. Isoform 2 was detected in the lung, liver and mature monocytes.|
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Provided below are standard protocols that you may find useful for product applications.
TREM1 Antibody: TREM1 (triggering receptor expressed on myeloid cells 1) is a receptor belonging to the Ig superfamily that amplifies neutrophil and monocyte-mediated inflammatory responses triggered by bacterial and fungal infections by stimulating release of pro-inflammatory chemokines and cytokines, as well as increased surface expression of cell activation markers. It is thought that TREM1 other related TREM proteins such as TREM2 act to modulate the inflammatory response. TREM1 has also been linked to inflammatory bowel disease resulting in enhanced production of TNF, IL-6, IL-8, and MCP-1.
Bouchon A, Facchetti F, Weigand MA, et al. TREM-1 amplifies inflammation and is a crucial mediator of septic shock. Nature 2001; 410:1103-7.
Ford JW and McVicar DW. TREM and TREM-like receptors in inflammation and disease. Curr. Opin. Immunol. 2009; 21:38-46
Schenk M, Bouchon A, Seibold F, et al. TREM-1-expressing intestinal macrophages crucially amplify chronic inflammation in experimental colitis and inflammatory bowel diseases. J. Clin. Invest. 2007; 117:3097-106.
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