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>   home   >   Products   >   Primary Antibodies   >   Stem Cells   >   CCL4 Antibody   

CCL4 Antibody

  • WB - CCL4 Antibody ASC11613
    Western blot analysis of CCL4 in rat brain tissue lysate with CCL4 antibody at 1 µg/mL.
  • IHC - CCL4 Antibody ASC11613
    Immunohistochemistry of CCL4 in rat brain tissue with CCL4 antibody at 2.5 µg/ml.
  • IF - CCL4 Antibody ASC11613
    Immunofluorescence of CCL4 in rat brain tissue with CCL4 antibody at 20 µg/ml.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P13236
Other Accession NP_002975, 4506845
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW Predicted: 10 kDa
Application Notes CCL4 antibody can be used for detection of CCL4 by Western blot at 1 - 2 µg/mL.
Additional Information
Gene ID 6351
Target/Specificity CCL4;
Reconstitution & Storage CCL4 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year.
PrecautionsCCL4 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CCL4
Synonyms LAG1, MIP1B, SCYA4
Function Monokine with inflammatory and chemokinetic properties. Binds to CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-beta induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form MIP-1-beta(3-69) retains the abilities to induce down-modulation of surface expression of the chemokine receptor CCR5 and to inhibit the CCR5- mediated entry of HIV-1 in T-cells. MIP-1-beta(3-69) is also a ligand for CCR1 and CCR2 isoform B.
Cellular Location Secreted.
Research Areas
Citations (0)

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CCL4 Antibody: CCL4, also known as macrophage inflammatory protein 1-beta (MIP1B), belongs to the intercrine beta (chemokine CC) family. Both CCL4 and the related protein CCL3 participate in the host response to invading bacterial, viral, parasite and fungal pathogens by regulating the trafficking and activation state of selected subgroups of inflammatory cells. While both CCL4 and CCL3 exert similar effects on monocytes, their effect on lymphocytes differ; with CCL4 selectively attracting CD4+ lymphocytes and CCL3 selectively attracting CD8+ lymphocytes. Additionally, both have been shown to be potent chemoattractants for B cells, eosinophils and dendritic cells. The processed form of CCL4 can induce down-modulation of surface expression of the chemokine receptor CCR5, thus inhibiting the CCR5-mediated entry of HIV-1 in T cells.


Baixeras E, Roman-Roman S, Jitsukawa S, et al. Cloning and expression of a lymphocyte activation gene (LAG-1). Mol. Immunol. 1990; 27:1091-102.
Maurer M and von Stebut E. Macrophage inflammatory protein-1. Int. J. Biochem. Cell Biol. 2004; 36:1882-6.
Margolis LB, Glushakova S, Grivel JC, et al. Blockade of CC chemokine receptor 5 (CCR5)-tropic human immunodeficiency virus-1 replication in human lymphoid tissue by CC chemokines. J. Clin. Invest. 1998; 101:1876-80.

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$ 310.00
Cat# ASC11613
(40 western blots)
Availability: 5-7days
Bulk Size
Seasonal Special on Bulk Order
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