|Application ||WB, IHC-P, IF, E|
|Other Accession||NP_003317, 4507603|
|Reactivity||Human, Mouse, Rat|
|Calculated MW||20 kDa|
|Application Notes||TNFSF4 antibody can be used for detection of TNFSF4 by Western blot at 0.5 - 1 µg/mL.|
|Target/Specificity||TNFSF4; At least two isoforms of TNFSF4 are known to exist; this antibody will detect both isoforms.|
|Reconstitution & Storage||TNFSF4 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year.|
|Precautions||TNFSF4 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Cytokine that binds to TNFRSF4. Co-stimulates T-cell proliferation and cytokine production.|
|Cellular Location||Membrane; Single-pass type II membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
TNFSF4 Antibody: The tumor necrosis factor superfamily member TNFSF4 is a type II membrane bound, non-covalently linked homotrimeric protein. It is expressed on antigen presenting cells, such as dendritic cells and activated B-cells, and also on other cells such as vascular endothelial cells, mast cells, and natural killer cells. TNFSF4 signals specifically through the TNFRSF4 receptor, is expressed predominantly on CD4+T cells but also on certain activated CD8+T cells. TNFRSF4/TNFSF4 functions as a costimulatory signal, which is required for a productive interaction between antigen presenting cells and their target T-cells. It enhances cell proliferation and survival, and increases expression of RANTES, IL-2, IL-3, and IFNγ. TNFRSF4/TNFSF4 signaling plays an important role in immunotolerance.
Arch RH and Thompson CB. 4-1BB and Ox40 are members of a tumor necrosis factor (TNF)-nerve growth factor receptor subfamily that bind TNF receptor-associated factors and activate nuclear factor kappaB. Mol. Cell Biol.1998; 18:558-65.
OX40-OX40 ligand interaction in T-cell-mediated immunity and immunopathy. Adv. Immunol. 2010; 105:63-98
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