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TNFSF4 Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, IF, E |
|---|---|
| Primary Accession | P23510 |
| Other Accession | NP_003317, 4507603 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Calculated MW | 20 kDa |
| Application Notes | TNFSF4 antibody can be used for detection of TNFSF4 by Western blot at 0.5 - 1 µg/mL. |
| Gene ID | 7292 |
|---|---|
| Target/Specificity | TNFSF4; At least two isoforms of TNFSF4 are known to exist; this antibody will detect both isoforms. |
| Reconstitution & Storage | TNFSF4 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. |
| Precautions | TNFSF4 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | TNFSF4 |
|---|---|
| Synonyms | TXGP1 |
| Function | Cytokine that binds to TNFRSF4. Co-stimulates T-cell proliferation and cytokine production. |
| Cellular Location | Membrane; Single-pass type II membrane protein. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
TNFSF4 Antibody: The tumor necrosis factor superfamily member TNFSF4 is a type II membrane bound, non-covalently linked homotrimeric protein. It is expressed on antigen presenting cells, such as dendritic cells and activated B-cells, and also on other cells such as vascular endothelial cells, mast cells, and natural killer cells. TNFSF4 signals specifically through the TNFRSF4 receptor, is expressed predominantly on CD4+T cells but also on certain activated CD8+T cells. TNFRSF4/TNFSF4 functions as a costimulatory signal, which is required for a productive interaction between antigen presenting cells and their target T-cells. It enhances cell proliferation and survival, and increases expression of RANTES, IL-2, IL-3, and IFNγ. TNFRSF4/TNFSF4 signaling plays an important role in immunotolerance.
References
Arch RH and Thompson CB. 4-1BB and Ox40 are members of a tumor necrosis factor (TNF)-nerve growth factor receptor subfamily that bind TNF receptor-associated factors and activate nuclear factor kappaB. Mol. Cell Biol.1998; 18:558-65.
OX40-OX40 ligand interaction in T-cell-mediated immunity and immunopathy. Adv. Immunol. 2010; 105:63-98
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