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>   home   >   Products   >   Primary Antibodies   >   Stem Cells   >   KREMEN1 Antibody   

KREMEN1 Antibody

  • WB - KREMEN1 Antibody ASC11626
    Western blot analysis of KREMEN1 in rat small intestine tissue lysate with KREMEN1 antibody at (A) 0.125 and (B) 0.25 µg/mL
  • IHC - KREMEN1 Antibody ASC11626
    Immunohistochemistry of KREMEN1 in human small intestine tissue with KREMEN1 antibody at 5 µg/ml.
  • IF - KREMEN1 Antibody ASC11626
    Immunofluorescence of KREMEN1 in human small intestine tissue with KREMEN1 antibody at 20 µg/ml.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q96MU8
Other Accession NP_114434, 24041012
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW 54 kDa
Application Notes KREMEN1 antibody can be used for detection of KREMEN1 by Western blot at 0.125 - 0.25 µg/mL.
Additional Information
Gene ID 83999
Target/Specificity KREMEN1; Three isoforms of KREMEN1 exists as a result of alternative splicing event.
Reconstitution & Storage KREMEN1 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year.
PrecautionsKREMEN1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms KREMEN, KRM1
Function Receptor for Dickkopf protein. Cooperates with Dickkopf to block Wnt/beta-catenin signaling (By similarity).
Cellular Location Membrane; Single-pass type I membrane protein
Research Areas
Citations (0)

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KREMEN1 Antibody: Kremen (Kringle containing protein marking the eye and the nose) proteins are type I transmembrane proteins that contain extracellular kringle, WSC and CUB domains and an intracellular region without any conserved motifs. Kremens bind a subset of the secreted Dickkopf proteins (Dkk 1, 2, and 4) with high affinity to modulate the canonical Wnt signaling pathway that is transduced by the ternary receptor complex composed of Wnt, Frizzled, and the LDL receptor related protein 5/6 (LRP5/6) coreceptor. KREMEN1 is a receptor for the Dickkopf protein which blocks Wnt/beta catenin signaling. It is necessary to ensure normal spatial and temporal patterns of Wnt activity during developmental processes.


Nakamura T, Aoki S, Kitajima K, et al. Molecular cloning and characterization of Kremen, a novel kringle-containing transmembrane protein. Biochim. Biophys. Acta. 2001; 1518:63-72.
Mao B, Wu W, Davidson G, et al. Kremen proteins are Dickkopf receptors that regulate Wnt/beta-catenin signalling. Nature 2002; 417:664-7.
Li J, Liu WM, Cao YJ, et al. Roles of Dickkopf-1 and its receptor Kremen1 during embryonic implantation in mice. Fertil. Steril. 2008; 90:1470-9.
Wang K, Zhang Y, Li X, et al. Characterization of the Kremen-binding site on Dkk1 and elucidation of the role of Kremen in Dkk-mediated Wnt antagonism. J. Biol. Chem. 2008; 283:23371-5.

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$ 310.00
Cat# ASC11626
(40 western blots)
Availability: 5-7days
Bulk Size
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