|Application ||WB, ICC, E|
|Other Accession||NP_757384, 27437008|
|Calculated MW||Predicted: 51 kDa |
Observed: 54 kDa
|Application Notes||KREMEN2 Antibody can be used for detection of KREMEN2 by Western blot starting at 1 µg/mL.|
|Target/Specificity||KREMEN2; Multiple isoforms of KREMEN2 are known to exist. KREMEN2 antibody is predicted to not cross-react with other Kremen protein family members.|
|Reconstitution & Storage||KREMEN2 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year.|
|Precautions||KREMEN2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Receptor for Dickkopf protein. Cooperates with Dickkopf to block Wnt/beta-catenin signaling. Forms a ternary complex with Dkk1 and LRP6 and induces rapid endocytosis and removal of the Wnt receptor LRP6 from the plasma membrane (By similarity).|
|Cellular Location||Membrane; Single-pass type I membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
KREMEN2 Antibody: Kremen (Kringle containing protein marking the eye and the nose) proteins are type I transmembrane proteins that contain extracellular kringle, WSC and CUB domains and an intracellular region without any conserved motifs. Kremens bind a subset of the secreted Dickkopf proteins (Dkk 1, 2, and 4) with high affinity to modulate the canonical Wnt signaling pathway that is transduced by the ternary receptor complex composed of Wnt, Frizzled, and the LDL receptor related protein 5/6 (LRP5/6) co-receptor. Recent experiments have shown that KREMEN2 is a regulator of bone remodeling and raise the possibility that antagonizing KREMEN2 might prove beneficial in patients with bone loss disorders.
Nakamura T, Aoki S, Kitajima K, et al. Molecular cloning and characterization of Kremen, a novel kringle-containing transmembrane protein. Biochim. Biophys. Acta. 2001; 1518:63-72.
Mao B, Wu W, Davidson G, et al. Kremen proteins are Dickkopf receptors that regulate Wnt/beta-catenin signalling. Nature 2002; 417:664-7.
Li J, Liu WM, Cao YJ, et al. Roles of Dickkopf-1 and its receptor KREMEN1 during embryonic implantation in mice. Fertil. Steril. 2008; 90:1470-9.
Schulze J, Seitz S, Saito H, et al. Negative regulation of bone formation by the transmembrane Wnt antagonist Kremen-2. PLoS 2010; 5:e10309.
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