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SHISA3 Antibody

  • WB - SHISA3 Antibody ASC11632
    Western blot analysis of SHISA3 in human small intestine Tissue lysate with SHISA3 antibody at 1 µg/mL in (A) the absence and (B) the presence of blocking peptide.
  • IHC - SHISA3 Antibody ASC11632
    Immunohistochemistry of SHISA3 in human small intestine tissue with SHISA3 antibody at 2.5 µg/ml.
  • IF - SHISA3 Antibody ASC11632
    Immunofluorescence of SHISA3 in human small intestine tissue with SHISA3 antibody at 20 µg/ml.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession A0PJX4
Other Accession NP_001073974, 122937450
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW Predicted: 26 kDa

Observed: 28 kDa
Application Notes SHISA3 Antibody can be used for detection of SHISA3 by Western blot at 1 µg/mL.
Additional Information
Gene ID 152573
Target/Specificity SHISA3; SHISA3 antibody is predicted to not cross-react with other SHISA protein family members.
Reconstitution & Storage SHISA3 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year.
PrecautionsSHISA3 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Function Plays an essential role in the maturation of presomitic mesoderm cells by individual attenuation of both FGF and WNT signaling.
Cellular Location Endoplasmic reticulum membrane; Single-pass type I membrane protein
Research Areas
Citations (0)

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SHISA3 Antibody: SHISA3 plays an essential role in the maturation of presomitic mesoderm cells by individual attenuation of both FGF and WNT signaling. The Shisa family of single-transmembrane proteins is characterized by an N-terminal cysteine-rich domain and a proline-rich C-terminal region. Its founding member, Xenopus Shisa, promotes head development by antagonizing Wnt and FGF signaling. Shisa physically interacted with immature forms of the Wnt receptor Frizzled and the FGF receptor within the ER and inhibited their posttranslational maturation and trafficking to the cell surface. Loss of Shisa function sensitized the neuroectoderm to Wnt signaling and suppressed head formation during gastrulation.


Furushima K, Yamamoto A, Nagano T, et al. Mouse homologues of Shisa antagonistic to Wnt and Fgf signalings. Dev. Biol. 2007; 306:480-92.
Pei J and Grishin NV. Unexpected diversity in Shisa-like proteins suggests the importance of their roles as transmembrane adaptors. Cell Signal. 2012; 24:758-69.
Yamamoto A, Nagano T, Takehara S, et al. Shisa promotes head formation through the inhibition of receptor protein maturation for the caudalizing factors, Wnt and FGF. Cell 2005; 120:223-35

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$ 310.00
Cat# ASC11632
(40 western blots)
Availability: 5-7days
Bulk Size
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