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SHISA4 Antibody

  • WB - SHISA4 Antibody ASC11633
    Western blot analysis of SHISA4 in human brain tissue lysate with SHISA4 antibody at (A) 1 and (B) 2 µg/mL.
  • IHC - SHISA4 Antibody ASC11633
    Immunohistochemistry of SHISA4 in mouse brain tissue with SHISA4 antibody at 2.5 µg/ml.
  • IF - SHISA4 Antibody ASC11633
    Immunofluorescence of SHISA4 in mouse brain tissue with SHISA4 antibody at 20 µg/ml.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q96DD7
Other Accession NP_937792, 269973884
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW Predicted: 22 kDa

Observed: 24 kDa
Application Notes SHISA4 Antibody can be used for detection of SHISA4 by Western blot starting at 1 µg/mL.
Additional Information
Gene ID 149345
Target/Specificity SHISA4; SHISA4 antibody is predicted to not cross-react with other SHISA protein family members.
Reconstitution & Storage SHISA4 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year.
PrecautionsSHISA4 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms C1orf40, TMEM58
Cellular Location Membrane; Single-pass type I membrane protein
Research Areas
Citations (0)

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SHISA4 Antibody: SHISA4 plays an essential role in the maturation of presomitic mesoderm cells by individual attenuation of both FGF and WNT signaling. The Shisa family of single-transmembrane proteins is characterized by an N-terminal cysteine-rich domain and a proline-rich C-terminal region. Its founding member, Xenopus Shisa, promotes head development by antagonizing Wnt and FGF signaling. Shisa physically interacted with immature forms of the Wnt receptor Frizzled and the FGF receptor within the ER and inhibited their posttranslational maturation and trafficking to the cell surface. Loss of Shisa function sensitized the neuroectoderm to Wnt signaling and suppressed head formation during gastrulation.


Furushima K, Yamamoto A, Nagano T, et al. Mouse homologues of Shisa antagonistic to Wnt and Fgf signalings. Dev. Biol. 2007; 306:480-92.
Pei J and Grishin NV. Unexpected diversity in Shisa-like proteins suggests the importance of their roles as transmembrane adaptors. Cell Signal. 2012; 24:758-69.
Yamamoto A, Nagano T, Takehara S, et al. Shisa promotes head formation through the inhibition of receptor protein maturation for the caudalizing factors, Wnt and FGF. Cell 2005; 120:223-35.

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$ 310.00
Cat# ASC11633
(40 western blots)
Availability: 5-7days
Bulk Size
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