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MTERFD2 Antibody

     
  • WB - MTERFD2 Antibody ASC11636
    Western blot analysis of MTERFD2 in human small intestine tissue lysate with MTERFD2 antibody at 1 µg/mL.
  • IHC - MTERFD2 Antibody ASC11636
    Immunohistochemistry of MTERFD2 in human small intestine tissue with MTERFD2 antibody at 2.5 µg/ml.
  • IF - MTERFD2 Antibody ASC11636
    Immunofluorescence of MTERFD2 in human small intestine tissue with MTERFD2 antibody at 20 µg/ml.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF, E
Primary Accession Q7Z6M4
Other Accession NP_872307, 42740903
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW Predicted: 42 kDa

Observed: 44 kDa
Application Notes MTERFD2 Antibody can be used for detection of MTERFD2 by Western blot at 1 µg/mL.
Additional Information
Gene ID 130916
Target/Specificity MTERFD2; At least three isoforms of MTERFD2 are known to exist. MTERFD2 antibody is predicted to not cross-react with other MTERFD protein family members.
Reconstitution & Storage MTERFD2 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year.
PrecautionsMTERFD2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name MTERF4
Synonyms MTERFD2
Function Regulator of mitochondrial ribosome biogenesis and translation. Binds to mitochondrial ribosomal RNAs 16S, 12S and 7S and targets NSUN4 RNA methyltransferase to the mitochondrial large ribosomal subunit (39S).
Cellular Location Mitochondrion
Citations (0)

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Background

MTERFD2 Antibody: Members of the mTERF (mitochondrial transcription termination factor) family, are mitochondrial proteins that are believed to be transcription termination factors. MTERFD2 is targeted to the mitochondria and is ubiquitously expressed, with highest expression levels in fore- and midbrain, diencephalon, spinal cord, tongue, lung liver and kidney. MTERFD2 has been suggested to play a role in organ differentiation during embryogenesis. A closely related mTERF family member, MTERFD3, is believed to be involved in cell cycle regulation and cell growth by modulating mitochondrial transcription.

References

Fernandez-Silva P, et al. The human mitochondrial transcription termination factor (mTERF) is a multizipper protein but binds to DNA as a monomer, with evidence pointing to intramolecular leucine zipper interactions. EMBO J. 1997; 16:1066-79.
Xu Q, Zhang F, He H, et al. Expression profile of mouse Mterfd2, a novel component of the mitochondrial transcription termination (MTERF) family. Genes Genet. Syst. 2011; 86:269-75.
Park CB, Asin-Cayuela J, Camara Y, et al. MTERF3 is a negative regulator of mammalian mtDNA transcription. Cell 2007; 130:273-85.

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$ 310.00
Cat# ASC11636
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