|Application ||WB, IHC-P, IF, E|
|Other Accession||NP_872307, 42740903|
|Reactivity||Human, Mouse, Rat|
|Calculated MW||Predicted: 42 kDa |
Observed: 44 kDa
|Application Notes||MTERFD2 Antibody can be used for detection of MTERFD2 by Western blot at 1 µg/mL.|
|Target/Specificity||MTERFD2; At least three isoforms of MTERFD2 are known to exist. MTERFD2 antibody is predicted to not cross-react with other MTERFD protein family members.|
|Reconstitution & Storage||MTERFD2 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year.|
|Precautions||MTERFD2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Regulator of mitochondrial ribosome biogenesis and translation. Binds to mitochondrial ribosomal RNAs 16S, 12S and 7S and targets NSUN4 RNA methyltransferase to the mitochondrial large ribosomal subunit (39S).|
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Provided below are standard protocols that you may find useful for product applications.
MTERFD2 Antibody: Members of the mTERF (mitochondrial transcription termination factor) family, are mitochondrial proteins that are believed to be transcription termination factors. MTERFD2 is targeted to the mitochondria and is ubiquitously expressed, with highest expression levels in fore- and midbrain, diencephalon, spinal cord, tongue, lung liver and kidney. MTERFD2 has been suggested to play a role in organ differentiation during embryogenesis. A closely related mTERF family member, MTERFD3, is believed to be involved in cell cycle regulation and cell growth by modulating mitochondrial transcription.
Fernandez-Silva P, et al. The human mitochondrial transcription termination factor (mTERF) is a multizipper protein but binds to DNA as a monomer, with evidence pointing to intramolecular leucine zipper interactions. EMBO J. 1997; 16:1066-79.
Xu Q, Zhang F, He H, et al. Expression profile of mouse Mterfd2, a novel component of the mitochondrial transcription termination (MTERF) family. Genes Genet. Syst. 2011; 86:269-75.
Park CB, Asin-Cayuela J, Camara Y, et al. MTERF3 is a negative regulator of mammalian mtDNA transcription. Cell 2007; 130:273-85.
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