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>   home   >   Products   >   Primary Antibodies   >   Cell Biology   >   WAC Antibody   

WAC Antibody

  • WB - WAC Antibody ASC11640
    Western blot analysis of WAC in human testis tissue lysate with WAC antibody at 1 µg/mL.
  • IHC - WAC Antibody ASC11640
    Immunohistochemistry of WAC in mouse testis tissue with WAC antibody at 2.5 µg/ml.
  • IF - WAC Antibody ASC11640
    Immunofluorescence of WAC in mouse testis tissue with WAC antibody at 5 µg/ml.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9BTA9
Other Accession NP_057712, 18379328
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW Predicted: 71 kDa

Observed: 75 kDa
Application Notes WAC Antibody can be used for detection of WAC by Western blot at 1 µg/mL.
Additional Information
Gene ID 51322
Target/Specificity WAC; At least two isoforms of WAC are known to exist; this antibody will detect the larger isoform.
Reconstitution & Storage WAC antibody can be stored at 4℃ for three months and -20℃, stable for up to one year.
PrecautionsWAC Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name WAC
Synonyms KIAA1844
Function Acts as a linker between gene transcription and histone H2B monoubiquitination at 'Lys-120' (H2BK120ub1). Interacts with the RNA polymerase II transcriptional machinery via its WW domain and with RNF20-RNF40 via its coiled coil region, thereby linking and regulating H2BK120ub1 and gene transcription. Regulates the cell-cycle checkpoint activation in response to DNA damage. Positive regulator of amino acid starvation-induced autophagy. May negatively regulate the ubiquitin proteasome pathway.
Cellular Location Nucleus speckle. Nucleus. Note=In distinct nuclear speckles Colocalizes with pre-mRNA processing complexes (By similarity)
Research Areas
Citations (0)

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WAC Antibody: The WW domain containing adaptor with coiled-coil protein (WAC) contains a WW domain that mediates protein-protein interactions and colocalizes with RNA splicing factor SC35. Further studies have indicated that WAC is a functional partner of the RNF20/40 complex that ubiquitinates Histone H2B, and that WAC regulates H2B ubiquitination. WAC targets RNF20/40 to associate with RNA polymerase II complex for H2B ubiquitination at active transcription sites. WAC-dependent transcription is also important for cell-cycle checkpoint activation in response to genotoxic stress.


Xu GM and Arnaout MA. WAC, a novel WW domain-containing adapter with a coiled-coil region, is colocalized with splicing factor SC35. Genomics 2002; 79:87-94.
Zhang F and Yu X. WAC, a functional partner of RNF20/40, regulates histone H2B ubiquitination and gene transcription. Mol. Cell 2011; 41:384-97.

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$ 310.00
Cat# ASC11640
(40 western blots)
Availability: 5-7days
Bulk Size
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