|Application ||WB, IHC-P, IF, E|
|Other Accession||NP_056278, 24308071|
|Reactivity||Human, Mouse, Rat|
|Calculated MW||Predicted: 18 kDa |
Observed: 16 kDa
|Application Notes||CNRIP1 antibody can be used for detection of CNRIP1 by Western blot at 1 - 2 µg/mL.|
|Target/Specificity||CNRIP1; At least two isoforms of CNRIP1 are known to exist; this antibody will detect both isoforms.|
|Reconstitution & Storage||CNRIP1 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year.|
|Precautions||CNRIP1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Isoform 1 suppresses cannabinoid receptor CNR1-mediated tonic inhibition of voltage-gated calcium channels. Isoform 2 does not have this effect.|
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Provided below are standard protocols that you may find useful for product applications.
CNRIP1 Antibody: The CNRIP1 (cannabinoid receptor interacting protein 1) protein is a G-protein coupled receptor which interacts with the C-terminal tail of cannabinoid receptor 1 (CB1) and is thought to play a role in synaptic plasticity, analgesia, appetite, and neuroprotection. One isoform of CNRIP1, CNRIP1a, modulates the constitutive CB1 receptor activity in the central nervous system (CNS), while the role of the shorter isoform CNRIP1b is yet unknown. CNRIP1 has been suggested as a potential target for CNS drug discovery.
Niehaus JL, Liu Y, Wallis KT, et al. CB1 cannabinoid receptor activity is modulated by the cannabinoid receptor interacting protein CRIP 1a. Mol. Pharmacol. 2007; 72:1557-66.
Smith TH, Sim-Selley LJ, and Selley DE. Cannabinoid CB1 receptor-interacting proteins: novel targets for central nervous system drug discovery. Br. J. Pharm. 2010; 160:454-66.
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