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KANK3 Antibody

     
  • WB - KANK3 Antibody ASC11648
    Western blot analysis of KANK3 in A431 cell lysate with KANK3 antibody at (A) 1 and (B) 2 µg/mL.
  • IHC - KANK3 Antibody ASC11648
    Immunohistochemistry of KANK3 in human kidney tissue with KANK3 antibody at 2.5 µg/ml.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession Q6NY19
Other Accession NP_940873, 157504499
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW Predicted: 90 kDa

Observed: 100 kDa
Application Notes KANK3 Antibody can be used for detection of KANK3 by Western blot starting at 1 µg/mL.
Additional Information
Gene ID 256949
Target/Specificity KANK3; Two alternatively spliced transcript variants encoding different isoforms have been identified.
Reconstitution & Storage KANK3 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year.
PrecautionsKANK3 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name KANK3
Synonyms ANKRD47
Function May be involved in the control of cytoskeleton formation by regulating actin polymerization.
Tissue Location Strongly expressed in breast, liver, lung, skeletal muscle and kidney.
Research Areas
Citations (0)

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Background

KANK3 Antibody: Ankyrins are membrane adaptor molecules that play important roles in the control of cytoskeleton formation by regulating actin polymerization. Like other members of the KANK family, KANK3 (KN motif and ankyrin repeat domain-containing protein 3), is thought to play a role in the formation of actin stress fibers. In zebrafish, the homolog of KANK3 interacts with the adaptor protein Numb, a protein implicated in multiple basic cellular processes, and is essential for epidermal integrity and neurulation, suggesting that KANK3 may play a similar role in higher organisms.

References

Zhu Y, Kakinuma N, Wang Y, et al. Kank proteins: a new family of ankyrin-repeat domain containing proteins. Biochim. Biophys. Acta 2008; 1780:128-33.
Roy BC, Kakinuma N, Kiyama R. Kank attenuates actin remodeling by preventing interaction between IRSp53 and Rac1. J. Cell Biol. 2009; 184:253-67.
Boggetti B, Jasik J, Takamiya M, et al. NBP, a zebrafish homolog of human Kank3, is a novel Numb interactor essential for epidermal integrity and neurulation. Dev. Biol. 2012; 365:164-74.

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$ 320.00
Cat# ASC11648
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