|Application ||WB, IHC-P, E|
|Other Accession||NP_940873, 157504499|
|Calculated MW||Predicted: 90 kDa |
Observed: 100 kDa
|Application Notes||KANK3 Antibody can be used for detection of KANK3 by Western blot starting at 1 µg/mL.|
|Target/Specificity||KANK3; Two alternatively spliced transcript variants encoding different isoforms have been identified.|
|Reconstitution & Storage||KANK3 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year.|
|Precautions||KANK3 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May be involved in the control of cytoskeleton formation by regulating actin polymerization.|
|Tissue Location||Strongly expressed in breast, liver, lung, skeletal muscle and kidney.|
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Provided below are standard protocols that you may find useful for product applications.
KANK3 Antibody: Ankyrins are membrane adaptor molecules that play important roles in the control of cytoskeleton formation by regulating actin polymerization. Like other members of the KANK family, KANK3 (KN motif and ankyrin repeat domain-containing protein 3), is thought to play a role in the formation of actin stress fibers. In zebrafish, the homolog of KANK3 interacts with the adaptor protein Numb, a protein implicated in multiple basic cellular processes, and is essential for epidermal integrity and neurulation, suggesting that KANK3 may play a similar role in higher organisms.
Zhu Y, Kakinuma N, Wang Y, et al. Kank proteins: a new family of ankyrin-repeat domain containing proteins. Biochim. Biophys. Acta 2008; 1780:128-33.
Roy BC, Kakinuma N, Kiyama R. Kank attenuates actin remodeling by preventing interaction between IRSp53 and Rac1. J. Cell Biol. 2009; 184:253-67.
Boggetti B, Jasik J, Takamiya M, et al. NBP, a zebrafish homolog of human Kank3, is a novel Numb interactor essential for epidermal integrity and neurulation. Dev. Biol. 2012; 365:164-74.
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