|Application ||WB, IHC-P, IF, E|
|Other Accession||NP_057254, 7706621|
|Reactivity||Human, Mouse, Rat|
|Calculated MW||Predicted: 31 kDa |
Observed: 30 kDa
|Application Notes||TLX2 antibody can be used for detection of TLX2 by Western blot at 0.5 - 1 µg/mL.|
|Target/Specificity||TLX2; TLX2 antibody is predicted to not cross-react with other TLX proteins.|
|Reconstitution & Storage||TLX2 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year.|
|Precautions||TLX2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Transcription activator that binds DNA elements with the consensus sequence 5'-CGGTAATTGG-3'. Binds DNA via its homeobox. Required for normal cell death of enteric neurons in the gastrointestinal tract. Required for normal development of the enteric nervous system, and for proper development of normal motility of the gastrointestinal tract (By similarity).|
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Provided below are standard protocols that you may find useful for product applications.
TLX2 Antibody: The Hox proteins play a role in patterns of embryonic development and cellular differentiation by regulating downstream target genes. TLX2, also known as homeobox11-like 1 (HOX11L1), is a DNA-binding nuclear transcription factor that appears to be crucial for the development of the peripheral nervous system. TLX2 is a downstream target of regulation by both PHOX2A and PHOX2B proteins during intestinal neuronal differentiation. In humans, loss-of-function of TLX2 may play a role in tumorigenesis of gastrointestinal stromal tumors.
Dear TN, Sanchez-Garcia I, and Rabbitts TH, et al. The Hox11 gene encodes a DNA-binding nuclear transcription factor belonging to a distinct family of homeobox genes. Proc. Natl. Acad. Sci. USA 1993; 90:4431-5.
Puliti A, Cinti R, Betsos N, et al. HOX11L1, a gene involved in peripheral nervous system development, maps to human chromosome 2p13.1>p12 and mouse chromosome 6C3-D1. Cytogenet. Cell Genet. 1999; 84:115-7.
Borghini S, Di Duca M, Santamaria G, et al. Transcriptional regulation of TLX2 and impaired intestinal innervation: possible role of the PHOX2A and PHOX2B genes. Eur. J. Human Genet. 2007; 15:848-55.
Borghini S, Bachetti T, Fava M, et al. The TLX2 homeobox gene is a transcriptional target of PHOX2B in neural crest derived cells. Biochem. J. 2006; 395:355-61.
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