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>   home   >   Products   >   Primary Antibodies   >   Neuroscience   >   TLX2 Antibody   

TLX2 Antibody

     
  • WB - TLX2 Antibody ASC11662
    Western blot analysis of TLX2 in rat brain tissue lysate with TLX2 antibody at (A) 0.5 and (B) 1 µg/mL.
  • IHC - TLX2 Antibody ASC11662
    Immunohistochemistry of TLX2 in rat brain tissue with TLX2 antibody at 2.5 µg/ml.
  • IF - TLX2 Antibody ASC11662
    Immunofluorescence of TLX2 in rat brain tissue with TLX2 antibody at 20 µg/ml.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF, E
Primary Accession O43763
Other Accession NP_057254, 7706621
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW Predicted: 31 kDa

Observed: 30 kDa
Application Notes TLX2 antibody can be used for detection of TLX2 by Western blot at 0.5 - 1 µg/mL.
Additional Information
Gene ID 3196
Target/Specificity TLX2; TLX2 antibody is predicted to not cross-react with other TLX proteins.
Reconstitution & Storage TLX2 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year.
PrecautionsTLX2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TLX2
Synonyms HOX11L1, NCX
Function Transcription activator that binds DNA elements with the consensus sequence 5'-CGGTAATTGG-3'. Binds DNA via its homeobox. Required for normal cell death of enteric neurons in the gastrointestinal tract. Required for normal development of the enteric nervous system, and for proper development of normal motility of the gastrointestinal tract (By similarity).
Cellular Location Nucleus.
Research Areas
Citations (0)

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Background

TLX2 Antibody: The Hox proteins play a role in patterns of embryonic development and cellular differentiation by regulating downstream target genes. TLX2, also known as homeobox11-like 1 (HOX11L1), is a DNA-binding nuclear transcription factor that appears to be crucial for the development of the peripheral nervous system. TLX2 is a downstream target of regulation by both PHOX2A and PHOX2B proteins during intestinal neuronal differentiation. In humans, loss-of-function of TLX2 may play a role in tumorigenesis of gastrointestinal stromal tumors.

References

Dear TN, Sanchez-Garcia I, and Rabbitts TH, et al. The Hox11 gene encodes a DNA-binding nuclear transcription factor belonging to a distinct family of homeobox genes. Proc. Natl. Acad. Sci. USA 1993; 90:4431-5.
Puliti A, Cinti R, Betsos N, et al. HOX11L1, a gene involved in peripheral nervous system development, maps to human chromosome 2p13.1>p12 and mouse chromosome 6C3-D1. Cytogenet. Cell Genet. 1999; 84:115-7.
Borghini S, Di Duca M, Santamaria G, et al. Transcriptional regulation of TLX2 and impaired intestinal innervation: possible role of the PHOX2A and PHOX2B genes. Eur. J. Human Genet. 2007; 15:848-55.
Borghini S, Bachetti T, Fava M, et al. The TLX2 homeobox gene is a transcriptional target of PHOX2B in neural crest derived cells. Biochem. J. 2006; 395:355-61.

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$ 310.00
Cat# ASC11662
Size:
Quantity:
(40 western blots)
Availability: 5-7days
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