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>   home   >   Products   >   Primary Antibodies   >   Cell Biology   >   DAP Antibody   

DAP Antibody

  • WB - DAP Antibody ASC11669
    Western blot analysis of DAP in human small intestine tissue lysate with DAP antibody at 1 µg/mL.
  • IHC - DAP Antibody ASC11669
    Immunohistochemistry of DAP in human small intestine tissue with DAP antibody at 5 µg/ml.
  • IF - DAP Antibody ASC11669
    Immunofluorescence of DAP in human small intestine tissue with DAP antibody at 20 µg/ml.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P51397
Other Accession NP_004385, 4758120
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW Predicted: 11 kDa

Observed: 11 kDa
Application Notes DAP antibody can be used for detection of DAP by Western blot at 1 - 2 µg/mL.
Additional Information
Gene ID 1611
Target/Specificity DAP; DAP antibody is human, mouse and rat reactive.
Reconstitution & Storage DAP antibody can be stored at 4℃ for three months and -20℃, stable for up to one year.
PrecautionsDAP Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name DAP
Synonyms DAP1
Function Negative regulator of autophagy. Involved in mediating interferon-gamma-induced cell death.
Research Areas
Citations (0)

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DAP Antibody: The Death-associated protein (DAP) is a basic proline-rich 15kDa protein that as a positive mediator of programmed cell death that is induced by interferon-gamma (1). DAP is also a direct substrate of mammalian target of rapamycin (mTOR), a serine/threonine kinase that regulates cell growth and cell cycle, and a negative regulator of autophagy. Under rich nutrient conditions, mTOR phosphorylates DAP at Ser3 and Ser51; under starvation conditions, these residues are dephosphorylated and DAP is converted into an active suppressor of autophagy (2).


Deiss LP, Feinstein E, Berissi H, et al. Identification of a novel serine/threonine kinase and a novel 15-kD protein as potential mediators of the gamma interferon-induced cell death. Genes Dev. 1995; 9:15-30.
Koren I, Reem E, and Kimchi A. DAP1, a novel substrate of mTOR, negatively regulates autophagy. Curr. Biol. 2010; 20:1093-8.

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$ 310.00
Cat# ASC11669
(40 western blots)
Availability: 5-7days
Bulk Size
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