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IL-17RA Antibody

     
  • WB - IL-17RA Antibody ASC11676
    Western blot analysis of IL17RA in A20 cell lysate with IL17RA antibody at 1 µg/mL.
  • IHC - IL-17RA Antibody ASC11676
    Immunohistochemistry of IL-17RA in human spleen tissue with IL-17RA antibody at 2.5 µg/ml.
  • IF - IL-17RA Antibody ASC11676
    Immunofluorescence of IL-17RA in human spleen tissue with IL-17RA antibody at 20 µg/ml.
  • SPECIFICATION
  • CITATIONS
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF, E
Primary Accession Q96F46
Other Accession NP_055154, 23238208
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW Predicted: 95 kDa

Observed: 135 kDa
Application Notes IL-17RA antibody can be used for detection of IL-17RA by Western blot at 1 - 2 µg/mL.
Additional Information
Gene ID 23765
Target/Specificity IL17RA; IL-17RA antibody is human, mouse and rat reactive. Multiple isoforms of IL-17RA are known to exist. This antibody is predicted to not cross-react with other IL-17 receptor subunits.
Reconstitution & Storage IL-17RA antibody can be stored at 4℃ for three months and -20℃, stable for up to one year.
PrecautionsIL-17RA Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name IL17RA
Synonyms IL17R
Function Receptor for IL17A (PubMed:17911633, PubMed:9367539). Receptor for IL17F (PubMed:19838198, PubMed:17911633). Binds to IL17A with higher affinity than to IL17F (PubMed:17911633). Binds IL17A and IL17F homodimers as part of a heterodimeric complex with IL17RC (PubMed:16785495). Also binds heterodimers formed by IL17A and IL17F as part of a heterodimeric complex with IL17RC (PubMed:18684971). Receptor for IL17C as part of a heterodimeric complex with IL17RE (PubMed:21993848). Activation of IL17RA leads to induction of expression of inflammatory chemokines and cytokines such as CXCL1, CXCL8/IL8 and IL6 (PubMed:16785495, PubMed:17911633, PubMed:18684971).
Cellular Location Isoform 1: Cell membrane; Single-pass type I membrane protein
Tissue Location Widely expressed.
Research Areas
Citations (0)

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Background

IL-17RA Antibody: Interleukin 17A (IL-17A) is a proinflammatory cytokine secreted by activated T-lymphocytes (1). It is a potent inducer of the maturation of CD34-positive hematopoietic precursors into neutrophils. IL-17RA is a ubiquitous type I membrane glycoprotein that binds with low affinity to IL-17A and IL-17F (1,2). IL-17A and its receptor play a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis (3,4). Defects in IL-17RA are the cause of familial candidiasis type 5 (CANDF5) which is a rare disorder with altered immune responses and impaired clearance of fungal infections (5).

References

Yao Z, Painter SL, Fanslow WC, et al. Human IL-17: a novel cytokine derived from T cells. J. Immunol. 1995; 155: 5483-6.
Yao Z, Fanslow WC, Seldin MF, et al. Herpesvirus saimiri encodes a new cytokine, IL-17, which binds to a novel cytokine receptor. Immunity 1995; 3:811-21.
Rickel EA, Siegel LA, Yoon BR, et al. Identification of functional roles for both IL-17RB and IL-17RA in mediating IL-25-induced activities. J. Immunol. 2008;181:4299-310.
Wang M, Wang L, Ren T, et al. IL-17A/IL-17RA interaction promoted metastasis of osteosarcoma cells. Cancer Biol. Ther. 2012;14(2).

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$ 320.00
Cat# ASC11676
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