|Application ||WB, IHC-P, E|
|Other Accession||NP_085045, 117956389|
|Reactivity||Human, Mouse, Rat|
|Calculated MW||Predicted: 18 kDa |
Observed: 26 kDa
|Application Notes||KHDC1 antibody can be used for detection of KHDC1 by Western blot at 1 - 2 µg/mL.|
|Target/Specificity||KHDC1; KHDC1 antibody is human, mouse and rat reactive. At least three isoforms of KHDC1 are known to exist; this antibody will only detect the longest isoform.|
|Reconstitution & Storage||KHDC1 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year.|
|Precautions||KHDC1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Cellular Location||Membrane; Multi-pass membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
KHDC1 Antibody: KHDC1 family members are K-homology (KH) domain-containing RNA binding proteins that are involved in various aspects of RNA metabolism, ranging from transcription to RNA splicing, transportation, translation, and stability (1). KHDC1 is highly expressed in oocytes and interacts with cytoplasmic polyadenylation element-binding protein 1 (CPEB1), a key translational regulator controlling the polyA length of mRNAs (2,3). KHDC1 functions as a global translational repressor and induces apoptosis through an ER-dependent signaling pathway and that the C-terminal putative trans-membrane motif (TMM) is critical for its activities (3,4).
Valverde R, Edwards L, and Regan L. Structure and function of KH domains. FEBS J. 2008; 275:2712–26.
Pierre A, Gautier M, Callebaut I, et al. Atypical structure and phylogenomic evolution of the new eutherian oocyte- and embryo-expressed KHDC1/DPPA5/ECAT1/OOEP gene family. Genomics 2007; 90:583-94.
Cai C, Liu J, Wang C, et al. KHDC1A, a novel translational repressor, induces endoplasmic reticulum-dependent apoptosis. DNA Cell Biol. 2012; 31:1447-57.
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