|Application ||WB, IHC-P, IF, E|
|Other Accession||NP_006278, 5454114|
|Reactivity||Human, Mouse, Rat|
|Calculated MW||Predicted: 33 kDa |
Observed: 30 kDa
|Application Notes||TFPI antibody can be used for detection of TFPI by Western blot at 1 - 2 µg/mL.|
|Target/Specificity||TFPI; TFPI antibody is human, mouse and rat reactive. At least two isoforms of TFPI are known to exist; this antibody will detect both isoforms.|
|Reconstitution & Storage||TFPI antibody can be stored at 4℃ for three months and -20℃, stable for up to one year.|
|Precautions||TFPI Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Inhibits factor X (X(a)) directly and, in a Xa-dependent way, inhibits VIIa/tissue factor activity, presumably by forming a quaternary Xa/LACI/VIIa/TF complex. It possesses an antithrombotic action and also the ability to associate with lipoproteins in plasma.|
|Cellular Location||Isoform Alpha: Secreted.|
|Tissue Location||Mostly in endothelial cells.|
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Provided below are standard protocols that you may find useful for product applications.
TFPI Antibody: Tissue factor pathway inhibitor (TFPI), also known as lipoprotein-associated coagulation inhibitor, is a protease inhibitor that regulates the tissue factor (TF)-dependent pathway of blood coagulation (1). TFPI is glycosylated and predominantly found in the vascular endothelium and plasma in both free forms and complexed with plasma lipoproteins. The coagulation process initiates with the formation of a factor VIIa-TF complex, which proteolytically activates additional proteases (factors IX and X) and ultimately leads to the formation of a fibrin clot. TFPI inhibits the activated factor X and VIIa-TF proteases in an autoregulatory loop (1).
Broze GJ Jr and Girard TJ. Tissue factor pathway inhibitor: structure-function. Front. Biosci. 17:262-80.
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