|Application ||WB, E|
|Other Accession||NP_004354, 98986445|
|Reactivity||Human, Mouse, Rat|
|Calculated MW||Predicted: 77 kDa |
|Application Notes||CEACAM5 antibody can be used for detection of CEACAM5 by Western blot at 1 - 2 µg/ml.|
|Target/Specificity||CEACAM5; CEACAM5 antibody is human, mouse and rat reactive. CEACAM5 antibody is predicted to not cross-react with other CEACAM protein family members.|
|Reconstitution & Storage||CEACAM5 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year.|
|Precautions||CEACAM5 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Cell surface glycoprotein that plays a role in cell adhesion and in intracellular signaling. Receptor for E.coli Dr adhesins.|
|Cellular Location||Cell membrane; Lipid-anchor, GPI-anchor|
|Tissue Location||Found in adenocarcinomas of endodermally derived digestive system epithelium and fetal colon|
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Provided below are standard protocols that you may find useful for product applications.
CEACAM5 is a member of the carcinoembryonic antigen (CEA) family, which belongs to the immunoglobulin superfamily (1,2). CEACAM proteins are involved in cell-cell recognition and modulate cellular processes that range from the shaping of tissue architecture and neovascularization to the regulation of insulin homeostasis and T-cell proliferation (2). CEACAM5 has been shown to be overexpressed in a majority of carcinomas and has been suggested to be a intercellular adhesion molecule involved in cancer invasion and metastasis (3).
Gold P and Freedman SO. Specific carinoembryonic antigens of the human digestive system. J. Exp. Med. 1965; 122:467-81.
Kuespert K, Pils S, and Hauck CR. CEACAMs: their role in physiology and pathophysiology. Curr. Opin. Cell Biol. 2006; 565-71.
Yoshioka T, Masuko T, Kotanagi H, et al. Homotypic adhesion though carcinoembryonic antigen plays a role in hepatic metastasis development. Jpn. J. Cancer Res. 1998; 89:177-85.
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