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WFDC2 Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, IF, E |
|---|---|
| Primary Accession | Q14508 |
| Other Accession | NP_006094, 56699495 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Calculated MW | Predicted: 14 kDa Observed: 20kDa |
| Application Notes | WFDC2 antibody can be used for detection of WFDC2 by Western blot at 1 - 2 µg/ml. |
| Gene ID | 10406 |
|---|---|
| Target/Specificity | WFDC2; WFDC2 antibody is human specific. Multiple isoforms of WFDC2 are known to exist. |
| Reconstitution & Storage | WFDC2 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. |
| Precautions | WFDC2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | WFDC2 |
|---|---|
| Synonyms | HE4, WAP5 |
| Function | Broad range protease inhibitor. |
| Cellular Location | Secreted |
| Tissue Location | Expressed in a number of normal tissues, including male reproductive system, regions of the respiratory tract and nasopharynx. Highly expressed in a number of tumors cells lines, such ovarian, colon, breast, lung and renal cells lines. Initially described as being exclusively transcribed in the epididymis |
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Provided below are standard protocols that you may find useful for product applications.
Background
The WAP four-disulfide core domain protein 2 (WFDC2), also known as epididymal protein 4, is a member of the WFDC domain family, a family of proteins that is characterized by the presence of Whey Acidic Protein (WAP) domain, and is highly expressed in the lung and salivary gland (1,2). Members of this family include SLPI and elafin, antiproteinases involved in the innate immune system (2). WFDC2 has been proposed to play a critical role in tumor formation and growth in ovarian cancer cells through the regulation of growth- and apoptosis-associated genes and may thus be a potential therapeutic target for epithelial ovarian cancer (3).
References
Drapkin R, von Horsten HH, Lin Y, et al. Human epididymis protein 4 (HE4) is a secreted glycoprotein that is overexpressed by serious and endometrioid ovarian carcinomas. Cancer Res. 2005; 65:2162-9.
Bingle L, Cross SS, High AS, et al. WFDC2 (HE4): A potential role in the innate immunity of the oral cavity and respiratory tract and the development of adenocarcinomas of the lung. Resp. Res. 2006; 7:61.
Chen Y, Mu X, Wang S, et al. WAP four-disulfide core domain protein 2 mediates the proliferation of human ovarian cancer cells through the regulation of growth- and apoptosis-associated genes. Oncol. Rep. 2013; 29:288-96.
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