|Application ||WB, IF, E|
|Other Accession||NP_008984, 5901910|
|Calculated MW||Predicted: 20 kDa |
|Application Notes||CD160 antibody can be used for detection of CD160 by Western blot at 1 - 2 µg/ml.|
|Target/Specificity||CD160; CD160 antibody is human and mouse reactive. Multiple isoforms of CD160 are known to exist.|
|Reconstitution & Storage||CD160 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year.|
|Precautions||CD160 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Receptor showing broad specificity for both classical and non-classical MHC class I molecules.|
|Cellular Location||Cell membrane; Lipid-anchor, GPI-anchor.|
|Tissue Location||Expressed in spleen, peripheral blood, and small intestine. Expression is restricted to functional NK and T cytotoxic lymphocytes EMBL; AF060981; AAC72302.1; -; mRNA EMBL; BC014465; AAH14465.1; -; mRNA CCDS; CCDS72861.1; - RefSeq; NP_008984.1; NM_007053.3 UniGene; Hs.488237; - UniGene; Hs.740780; - ProteinModelPortal; O95971; - SMR; O95971; - BioGrid; 116299; 41 IntAct; O95971; 9 MINT; O95971; - STRING; 9606.ENSP00000235933; - iPTMnet; O95971; - PhosphoSitePlus; O95971; - BioMuta; CD160; - EPD; O95971; - PaxDb; O95971; - PeptideAtlas; O95971; - PRIDE; O95971; - ProteomicsDB; 51154; - DNASU; 11126; - Ensembl; ENST00000235933; ENSP00000235933; ENSG00000117281 Ensembl; ENST00000369288; ENSP00000358294; ENSG00000117281 GeneID; 11126; - KEGG; hsa:11126; - CTD; 11126; - DisGeNET; 11126; - EuPathDB; HostDB:ENSG00000117281.15; - GeneCards; CD160; - HGNC; HGNC:17013; CD160 MIM; 604463; gene neXtProt; NX_O95971; - OpenTargets; ENSG00000117281; - PharmGKB; PA134943137; - eggNOG; ENOG410IX7D; Eukaryota eggNOG; ENOG411156J; LUCA GeneTree; ENSGT00390000007258; - HOVERGEN; HBG018849; - InParanoid; O95971; - KO; K06542; - PhylomeDB; O95971; - TreeFam; TF338321; - Reactome; R-HSA-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell GeneWiki; CD160; - GenomeRNAi; 11126; - PRO; PR:O95971; - Proteomes; UP000005640; Chromosome 1 Bgee; ENSG00000117281; - CleanEx; HS_CD160; - ExpressionAtlas; O95971; baseline and differential Genevisible; O95971; HS GO; GO:0046658; C:anchored component of plasma membrane; IDA:HGNC GO; GO:0005886; C:plasma membrane; TAS:Reactome GO; GO:0032393; F:MHC class I receptor activity; IDA:HGNC GO; GO:0038023; F:signaling receptor activity; TAS:ProtInc GO; GO:0005102; F:signaling receptor binding; IDA:HGNC GO; GO:0008283; P:cell proliferation; TAS:ProtInc GO; GO:0007166; P:cell surface receptor signaling pathway; TAS:ProtInc GO; GO:0006968; P:cellular defense response; TAS:ProtInc GO; GO:0050829; P:defense response to Gram-negative bacterium; IEA:Ensembl GO; GO:0050776; P:regulation of immune response; TAS:Reactome Gene3D; 22.214.171.124; -; 1 InterPro; IPR036179; Ig-like_dom_sf InterPro; IPR013783; Ig-like_fold SUPFAM; SSF48726; SSF48726; 1 1: Evidence at protein level; Cell membrane; Complete proteome; Disulfide bond; Glycoprotein; GPI-anchor; Immunoglobulin domain; Lipoprotein; Membrane; Polymorphism; Receptor; Reference proteome; Signal SIGNAL 1 26 CHAIN 27 159 CD160 antigen /FTId=PRO_0000014543 PROPEP 160 181 Removed in mature form. /FTId=PRO_0000014544 DOMAIN 27 122 Ig-like V-type LIPID 159 159 GPI-anchor amidated serine CARBOHYD 28 28 N-linked (GlcNAc...) asparagine CARBOHYD 137 137 N-linked (GlcNAc...) asparagine DISULFID 44 112 DISULFID 61 68 VARIANT 91 91 I -> V (in dbSNP:rs2231373) /FTId=VAR_027747 SEQUENCE 181 AA; 19810 MW; EF0B981ACC7478BD CRC64; MLLEPGRGCC ALAILLAIVD IQSGGCINIT SSASQEGTRL NLICTVWHKK EEAEGFVVFL CKDRSGDCSP ETSLKQLRLK RDPGIDGVGE ISSQLMFTIS QVTPLHSGTY QCCARSQKSG IRLQGHFFSI LFTETGNYTV TGLKQRQHLE FSHNEGTLSS GFLQEKVWVM LVTSLVALQA L|
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Provided below are standard protocols that you may find useful for product applications.
CD160, also known as BY55, is a lipid-anchored cell membrane glycoprotein that contains one immunoglobulin-like domain (1). It is expressed in small intestine, spleen and functional NK and T cytotoxic lymphocytes (1,2). CD160 exists as a disulfide-linked homomultimer that functions as a receptor for MHC (major histocompatability complex) molecules and is thought to regulate the function of NK cells (2,3). Additionally, CD160 interacts with TNFRSF14 and, via this interaction, is able to negatively regulate CD4+ T cell activation, indicating a role in immune system regulation (4).
Anumanthan A, Bensussan A, Boumsell L, et al. Cloning of BY55, a novel Ig superfamily member expressed on NK cells, CTL, and intestinal intraepithelial lymphocytes. J. Immunol. 1998; 161:2780-90.
Agrawal S, Marquet J, Freeman GJ, et al. Cutting edge: MHC class I triggering by a novel cell surface ligand costimulates proliferation of activated human T cells. J. Immunol. 1999; 162:1223-6.
Le Bouteiller P, Tabiasco J, Polgar B, et al. CD160: a unique activating NK cell receptor. Immunol. Lett. 2011;138:93-6
Chabot S, Jabrane-Ferrat N, Bigot K, et al. A novel antiangiogenic and vascular normalization therapy targeted against human CD160 receptor. J. Exp. Med. 2011; 208:973-86.
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