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IL-12A Antibody

  • WB - IL-12A Antibody ASC11706
    Western blot analysis of IL-12A in HeLa cell lysate with IL-12A antibody at 0.5 µg/ml in (A) the absence and (B) the presence of blocking peptide.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P29459
Other Accession NP_000873, 24430219
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW Predicted: 22 kDa

Observed: 22 kDa
Application Notes IL-12A antibody can be used for detection of IL-12A by Western blot at 0.5 - 1 µg/ml.
Additional Information
Gene ID 3592
Target/Specificity IL 12A; IL-12A antibody is human specific. IL-12A antibody will not cross-react with IL-12B.
Reconstitution & Storage IL-12A antibody can be stored at 4℃ for three months and -20℃, stable for up to one year.
PrecautionsIL-12A Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name IL12A
Synonyms NKSF1
Function Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine- activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC.
Cellular Location Secreted.
Research Areas
Citations (0)

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IL-12A is subunit of the cytokine IL-12 which acts on T- and natural killer cells, and has a broad array of biological activities. IL-12 is a disulfide-linked heterodimer composed of the 35-kD subunit and a 40-kD subunit that is a member of the cytokine receptor family (1). IL-12 is required for the T-cell-independent induction of interferon (IFN)-gamma, and is important for the differentiation of both Th1 and Th2 cells (1,2). The responses of lymphocytes to IL-12 are mediated by the activator of transcription protein STAT4 (2). Nitric oxide synthase 2A (NOS2A/NOS2) is found to be required for the signaling process of this cytokine in innate immunity (3).


Gee K, Guzzo C, Che Mat NF, et al. The IL-12 family of cytokines in infection, inflammation and autoimmune disorders. Inflamm. Allergy Drug Targets 2009; 8:40-52.
Sinigaglia F, D’Ambrosio D, Panina-Bordignon P, et al. Regulation of the IL-12/IL-12R axis: a critical step in T-helper cell differentiation and effector function. Immunol. Rev. 1999; 170:65-72.
Bogdan C, Rollinghoff M, and Diefenbach A. The role of nitric oxide in innate immunity. Immunol. Rev. 2000; 173:17-26.

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$ 310.00
Cat# ASC11706
(40 western blots)
Availability: 5-7days
Bulk Size
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