|Application ||WB, IHC-P, E|
|Other Accession||NP_775184, 27894307|
|Calculated MW||Predicted: 17 kDa |
Observed: 20 kDa
|Application Notes||IL-1F10 antibody can be used for detection of IL-1F10 by Western blot at 1 - 2 µg/ml|
|Target/Specificity||IL1F10; IL-1F10 antibody is human, mouse and rat reactive. Two isoforms of IL-1F10 exist.|
|Reconstitution & Storage||IL-1F10 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year.|
|Precautions||IL-1F10 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||FIL1T, IL1HY2, IL38|
|Function||Cytokine with immunomodulatory activity. Alone, does not induce cytokine production, but reduces IL22 and IL17A production by T-cells in response to heat-killed Candida albicans. Reduces IL36G-induced production of IL8 by peripheral blood mononuclear cells. Increases IL6 production by dendritic cells stimulated by bacterial lipopolysaccharides (LPS). Ligand for IL-36R/IL1RL2.|
|Tissue Location||Expressed in fetal skin, spleen and tonsil. Expressed mostly in the basal epithelia of skin and in proliferating B-cells of the tonsil|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
email@example.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
The cytokine IL-1 is responsible for initiating a variety of activities through the activation of transcription factors, NF-kappa B and AP-1, thereby promoting host response to injury or infection (1). IL-1F10 (Interleukin-1 family member 10), also known as FIL1T, IL1HY2 or FKSG75, is highly expressed in the skin, spleen and proliferating B-cells of the tonsil (2). IL-1F10 binds soluble IL-1 receptor type 1, and is one of nine Interleukin 1 families clustered on chromosome 2, where it is thought to participate in the regulation of adapted and innate immune responses (3). IL-1F10 and IL-1RN polymorphisms may play an important role in the susceptibility to developing rheumatoid arthritis (4).
Towne JE, Garka KE, Renshaw BR, et al. Interleukin (IL)-1F6, IL-1F8, and IL-1F9 signal through IL-1Rrp2 and IL-1RAcP to activate the pathway leading to NF-kappaB and MAPKs. J. Biol. Chem. 2004; 279:13677-88.
Lin H, Ho AS, Haley-Vicente D, et al. Cloning and characterization of IL-1HY2, a novel interleukin-1 family member. J. Biol. Chem. 2001; 276: 20597-602.
Bensen JT, Dawson PA, Mychaleckyj JC, et al. Identification of a novel human cytokine gene in the interleukin gene cluster on chromosome 2q12-14. J. Interferon Cytokine Res. 2001; 21:899-904.
Cruz-Robles D, Chavez-Gonzalez JP, Cavazos-Quero MM, et al. Association between IL-1B and IL-1RN gene polymorphisms and Chagas' disease development susceptibility. Immunol. Invest. 2009; 38:231-9.
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at firstname.lastname@example.org.