|Application ||WB, IHC-P, E|
|Other Accession||NP_775184, 27894307|
|Calculated MW||Predicted: 17 kDa |
Observed: 20 kDa
|Application Notes||IL-1F10 antibody can be used for detection of IL-1F10 by Western blot at 1 - 2 µg/ml|
|Target/Specificity||IL1F10; IL-1F10 antibody is human, mouse and rat reactive. Two isoforms of IL-1F10 exist.|
|Reconstitution & Storage||IL-1F10 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year.|
|Precautions||IL-1F10 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||FIL1T, IL1HY2, IL38|
|Function||Cytokine with immunomodulatory activity. Alone, does not induce cytokine production, but reduces IL22 and IL17A production by T-cells in response to heat-killed Candida albicans. Reduces IL36G-induced production of IL8 by peripheral blood mononuclear cells. Increases IL6 production by dendritic cells stimulated by bacterial lipopolysaccharides (LPS). Ligand for IL-36R/IL1RL2.|
|Tissue Location||Expressed in fetal skin, spleen and tonsil. Expressed mostly in the basal epithelia of skin and in proliferating B-cells of the tonsil|
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Provided below are standard protocols that you may find useful for product applications.
The cytokine IL-1 is responsible for initiating a variety of activities through the activation of transcription factors, NF-kappa B and AP-1, thereby promoting host response to injury or infection (1). IL-1F10 (Interleukin-1 family member 10), also known as FIL1T, IL1HY2 or FKSG75, is highly expressed in the skin, spleen and proliferating B-cells of the tonsil (2). IL-1F10 binds soluble IL-1 receptor type 1, and is one of nine Interleukin 1 families clustered on chromosome 2, where it is thought to participate in the regulation of adapted and innate immune responses (3). IL-1F10 and IL-1RN polymorphisms may play an important role in the susceptibility to developing rheumatoid arthritis (4).
Towne JE, Garka KE, Renshaw BR, et al. Interleukin (IL)-1F6, IL-1F8, and IL-1F9 signal through IL-1Rrp2 and IL-1RAcP to activate the pathway leading to NF-kappaB and MAPKs. J. Biol. Chem. 2004; 279:13677-88.
Lin H, Ho AS, Haley-Vicente D, et al. Cloning and characterization of IL-1HY2, a novel interleukin-1 family member. J. Biol. Chem. 2001; 276: 20597-602.
Bensen JT, Dawson PA, Mychaleckyj JC, et al. Identification of a novel human cytokine gene in the interleukin gene cluster on chromosome 2q12-14. J. Interferon Cytokine Res. 2001; 21:899-904.
Cruz-Robles D, Chavez-Gonzalez JP, Cavazos-Quero MM, et al. Association between IL-1B and IL-1RN gene polymorphisms and Chagas' disease development susceptibility. Immunol. Invest. 2009; 38:231-9.
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