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IL-36RN Antibody

  • WB - IL-36RN Antibody ASC11713
    Western blot analysis of IL-36RN in 3T3 cell lysate with IL-36RN antibody at 1 µg/ml in (A) the absence and (B) the presence of blocking peptide.
  • IHC - IL-36RN Antibody ASC11713
    Immunohistochemistry of IL-36RN in rat small intestine tissue with IL-36RN antibody at 5 µg/mL.
  • IF - IL-36RN Antibody ASC11713
    Immunofluorescence of IL-36RN in rat small intestine tissue with IL-36RN antibody at 20 µg/mL.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9UBH0
Other Accession NP_775262, 27894310
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW Predicted: 17 kDa

Observed: 27 kDa
Application Notes IL-36RN antibody can be used for detection of IL-36RN by Western blot at 1 - 2 µg/ml.
Additional Information
Gene ID 26525
Target/Specificity IL36RN; IL-36RN antibody is human specific. At least two isoforms of IL-36RN are known to exist
Reconstitution & Storage IL-36RN antibody can be stored at 4℃ for three months and -20℃, stable for up to one year.
PrecautionsIL-36RN Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name IL36RN
Synonyms FIL1D, IL1F5, IL1HY1, IL1L1, IL1RP3
Function Inhibits the activity of interleukin-36 (IL36A,IL36B and IL36G) by binding to receptor IL1RL2 and preventing its association with the coreceptor IL1RAP for signaling. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor. Proposed to play a role in skin inflammation. May be involved in the innate immune response to fungal pathogens, such as Aspergillus fumigatus. May activate an anti-inflammatory signaling pathway by recruiting SIGIRR.
Cellular Location Secreted.
Tissue Location Predominantly expressed in skin keratinocytes but not in fibroblasts, endothelial cells or melanocytes. Detected also in the spleen, brain leukocyte and macrophage cell types Increased in lesional psoriasis skin
Research Areas
Citations (0)

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IL-36RN is is a member of the interleukin 1 cytokine family whose gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2 (1). IL-36RN specifically inhibits the activation of NF-kappaB induced IL-36A (2). The opposing activities of these cytokines have been suggested to be involved in the regulation of skin inflammation (3). Like the IL-36 cytokines (IL-36A, IL-36B and IL-36G), IL-36RN requires post-translational processing for full agonist activity, but the cleavage mechanism is currently unknown (4).


Smith DE, Renshaw BR, Ketchem RR, et al. Four new members expand the interleukin-1 superfamily. J. Biol. Chem. 2000; 275:1169-75.
Debets R, Timans JC, Homey B, et al. Two novel IL-1 family members, IL-1 delta and IL-1 epsilon, function as an antagonist and agonist of NF-kappa B activation through the orphan IL-1 receptor-related protein 2. J. Immunol. 2001; 167:1440-6.
Blumberg H, Dinh H, Trueblood ES, et al. Opposing activities of two novel members of the IL-1 ligand family regulate skin inflammation. J. Exp. Med. 2007; 204:2603-14.
Towne JE, Renshaw BR, Douangpanya J, et al. Interleukin-36 (IL-36) ligands require processing for full agonist agonist (IL-36a, IL-36b, and IL-36g) or antagonist (IL-36Ra) activity. J. Biol. Chem. 2011; 286:42594-602.

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$ 310.00
Cat# ASC11713
(40 western blots)
Availability: 5-7days
Bulk Size
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