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ADROPIN Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, IF, E |
|---|---|
| Primary Accession | Q6UWT2 |
| Other Accession | NP_940975, 58218977 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Calculated MW | Predicted: 8 kDa Observed: 16 kDa |
| Application Notes | ADROPIN antibody can be used for detection of ADROPIN by Western blot at 1 - 2 µg/ml. Antibody can also be used for Immunohistochemistry starting at 5 µg/mL. For immunofluorescence start at 20 µg/mL. |
| Gene ID | 375704 |
|---|---|
| Target/Specificity | ENHO; ADROPIN antibody is human, mouse and rat reactive. Despite its predicted molecular weight, ADROPIN often migrates at a higher than expected molecular weight in SDS-PAGE. |
| Reconstitution & Storage | ADROPIN antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. |
| Precautions | ADROPIN Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | ENHO |
|---|---|
| Synonyms | C9orf165 |
| Function | Involved in the regulation of glucose homeostasis and lipid metabolism. |
| Cellular Location | Secreted. |
| Tissue Location | Expressed in liver and brain. |
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Provided below are standard protocols that you may find useful for product applications.
Background
ADROPIN is a recently identified protein that has been implicated in the maintenance of energy homeostasis and insulin resistance (1-3). ADROPIN expression is regulated by energy status and dietary nutrient content and is altered by obesity and regulates the expression of hepatic lipogenic genes and adipose tissue peroxisome proliferator-activated receptor gamma (PPAR-gamma) (1). ADROPIN levels increase with dietary fat content (2). ADROPIN has also been proposed to play a role in the regulation of endothelial function (3).
References
Kumar KG, Trevaskis JL, Lam DD, et al. Identification of Adropin as a secreted factor linking dietary macronutrient intake with energy homeostasis and lipid metabolism. Cell Metab. 2008; 8:468-81.
Kumar KG, Zhang J, Gao S, et al. Adropin deficiency is associated with increased adiposity and insulin resistance. Obesity 2012; 1394-402.
Lovren F, Pan Y, Quan A, et al. Adropin is a novel regulator of endothelial function. Circulation 2010; 122:S185-92.
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