|Application ||WB, IHC-P, IF, E|
|Other Accession||NP_940975, 58218977|
|Reactivity||Human, Mouse, Rat|
|Calculated MW||Predicted: 8 kDa |
Observed: 16 kDa
|Application Notes||ADROPIN antibody can be used for detection of ADROPIN by Western blot at 1 - 2 µg/ml. Antibody can also be used for Immunohistochemistry starting at 5 µg/mL. For immunofluorescence start at 20 µg/mL.|
|Target/Specificity||ENHO; ADROPIN antibody is human, mouse and rat reactive. Despite its predicted molecular weight, ADROPIN often migrates at a higher than expected molecular weight in SDS-PAGE.|
|Reconstitution & Storage||ADROPIN antibody can be stored at 4℃ for three months and -20℃, stable for up to one year.|
|Precautions||ADROPIN Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Involved in the regulation of glucose homeostasis and lipid metabolism.|
|Tissue Location||Expressed in liver and brain.|
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Provided below are standard protocols that you may find useful for product applications.
ADROPIN is a recently identified protein that has been implicated in the maintenance of energy homeostasis and insulin resistance (1-3). ADROPIN expression is regulated by energy status and dietary nutrient content and is altered by obesity and regulates the expression of hepatic lipogenic genes and adipose tissue peroxisome proliferator-activated receptor gamma (PPAR-gamma) (1). ADROPIN levels increase with dietary fat content (2). ADROPIN has also been proposed to play a role in the regulation of endothelial function (3).
Kumar KG, Trevaskis JL, Lam DD, et al. Identification of Adropin as a secreted factor linking dietary macronutrient intake with energy homeostasis and lipid metabolism. Cell Metab. 2008; 8:468-81.
Kumar KG, Zhang J, Gao S, et al. Adropin deficiency is associated with increased adiposity and insulin resistance. Obesity 2012; 1394-402.
Lovren F, Pan Y, Quan A, et al. Adropin is a novel regulator of endothelial function. Circulation 2010; 122:S185-92.
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